--- product_id: 74567161 title: "Life Extension Same, S-Adenosyl-Methionine, 400 mg, Mood and Liver Health and Joint Support Supplement, Non-GMO, Vegetarian, Gluten Free, 60 enteric-Coated Tablets" brand: "life extension" price: "Β₯11684" currency: JPY in_stock: true reviews_count: 13 category: "Life Extension" url: https://www.desertcart.jp/products/74567161-life-extension-same-s-adenosyl-methionine-400-mg-mood-liver store_origin: JP region: Japan --- # Non-GMO, vegetarian & gluten-free 400 mg potent SAMe dose Enteric-coated for max absorption Life Extension Same, S-Adenosyl-Methionine, 400 mg, Mood and Liver Health and Joint Support Supplement, Non-GMO, Vegetarian, Gluten Free, 60 enteric-Coated Tablets **Brand:** life extension **Price:** Β₯11684 **Availability:** βœ… In Stock ## Summary > πŸ’₯ Elevate your mood, joints & liver health β€” because thriving is the new baseline! ## Quick Answers - **What is this?** Life Extension Same, S-Adenosyl-Methionine, 400 mg, Mood and Liver Health and Joint Support Supplement, Non-GMO, Vegetarian, Gluten Free, 60 enteric-Coated Tablets by life extension - **How much does it cost?** Β₯11684 with free shipping - **Is it available?** Yes, in stock and ready to ship - **Where can I buy it?** [www.desertcart.jp](https://www.desertcart.jp/products/74567161-life-extension-same-s-adenosyl-methionine-400-mg-mood-liver) ## Best For - life extension enthusiasts ## Why This Product - Trusted life extension brand quality - Free international shipping included - Worldwide delivery with tracking - 15-day hassle-free returns ## Key Features - β€’ **Joint Joy:** Promotes healthy joint tissue and flexibility to keep you moving comfortably every day. - β€’ **Liver Shield:** Boosts glutathione production, a powerful antioxidant that protects liver cells from oxidative stress. - β€’ **Mood Mastery:** Clinically studied 400 mg SAMe supports emotional balance and a positive mental outlook. - β€’ **Pure & Trusted:** Non-GMO, gluten-free, vegetarian formula made in the USA with rigorous quality control and Certificate of Analysis. - β€’ **Long-Lasting Potency:** Enteric-coated tablets ensure stability and maximum absorption, delivering consistent results you can rely on. ## Overview Life Extension SAMe 400 mg is a premium, scientifically-backed supplement designed to support stable mood, joint comfort, and liver health. Featuring 60 enteric-coated, non-GMO vegetarian tablets, this formula enhances glutathione production for antioxidant liver protection while promoting joint tissue function. Manufactured in the USA with strict quality standards, it’s a trusted choice for professionals seeking holistic wellness and sustained vitality. ## Description SAMe (S-Adenosyl-Methionine) is a popular nutrient formula for mood health, joint health and liver health. This mood support supplement contains 400 mg of clinically studied S-Adenosyl-Methionine in every dose. SAMe benefits many metabolic functions in the body, from mood and joint health to healthy glutathione production. SAMe contains 60 enteric-coated vegetarian tablets, enough for a 20- to 60-day supply. Non-GMO. Manufactured in the USA. Review: Real Results - Ordered 11 More Boxes! - The formula S-Adenosyl-Methionine (SAMe) is one of the most versatile and well-researched compounds. It participates in methylation processes that affect the nervous system, liver, and connective tissues. This dual action makes the formula unique: it supports emotional balance, helps restore cartilage, and improves joint flexibility. Each tablet is individually sealed in foil to prevent oxidation and maintain the stability of the active ingredient. This ensures the formula remains effective throughout its entire shelf life. The brand has long established itself as a reliable creator of thoughtfully developed supplements. Every product is marked by consistent quality and attention to detail, and this formula is an excellent example of their high standards. UPDATE - November 30, 2025: After just a week and a half, I noticed such significant changes that when I saw it was on sale, I immediately ordered 11 more boxes! I originally purchased this SAMe supplement only for joint support - my mood was fine, but I discovered it could be even better! I was surprised - not only did my joints feel much better, but my mood improved significantly as well. The dual-action formula truly works! Even starting with one tablet, I felt positive results. You can adjust the dosage based on your needs and how you feel. I take mine early in the morning on an empty stomach for best results. I’ve been using it for about a month now, and the results continue to impress me. The improvement in joint comfort is especially remarkable. If you’re considering this product, I highly recommend it. The results have been wonderful in every way - both for joint support and emotional well-being. Very happy with this purchase! Review: Very Helpful Product - A long time ago my doctor told me to get this for depression. I've used it now for a long time and I won't change to other brands. ## Features - A reason to smile – S-Adenosyl-Methionine (SAMe) is made naturally by your body. It has a variety of well-studied benefits, including that supplementing with SAMe helps maintain a stable mood and healthy mental outlook. - Comfortable joints – SAMe helps promote joint tissue health and function. SAMe levels decline over time, so getting this daily, high-quality SAMe supplement will help keep you comfortable from head to toe! - Liver protection – S-Adenosyl-Methionine (SAMe) helps your body produce glutathione, a powerful antioxidant that helps protect liver cells from oxidizing free radical compounds. - Ingredients matter – We use the finest raw ingredients with the quality and purity you deserve. The majority of our products are non-GMO, gluten-free and manufactured in the USAβ€”and a Certificate of Analysis is available for every one. - Live your healthiest life – We believe the answers to a healthier life are in reach, and that scientific research is the key to getting there. That’s why so many of our formulas feature specific ingredients and amounts based on scientific studies. ## Technical Specifications | Specification | Value | |---------------|-------| | ASIN | B07D2KF4TL | | Age Range Description | Adult | | Allergen Information | Gluten Free | | Best Sellers Rank | #17,116 in Health & Household ( See Top 100 in Health & Household ) #428 in Blended Vitamin & Mineral Supplements | | Brand | Life Extension | | Brand Name | Life Extension | | Color | Yellow Ochre | | Container Type | Bottle | | Customer Reviews | 4.6 out of 5 stars 798 Reviews | | Diet Type | Vegetarian | | Dosage Form | Tablet | | Flavor | Unflavored | | Global Trade Identification Number | 00737870217466 | | Item Dimensions | 2.25 x 2.25 x 5 inches | | Item Form | Tablet | | Item Weight | 0.22 Pounds | | Manufacturer | Life Extension | | Manufacturer Part Number | 02174 | | Material Features | GMO Free | | Material Type Free | Non-GMO | | Model Name | SAMe 400 mg | | Model Number | 02174 | | Number of Items | 1 | | Primary Supplement Type | S-Adenosyl-Methionine | | Product Benefits | Helps maintain stable mood, Promotes liver health, Supports healthy joint function | | Special Ingredients | S-Adenosyl-Methionine | | Specific Uses For Product | Joint Health, Liver Health & Detox, Mood Support | | Total Servings Per Container | 60.0 | | UPC | 737870217466 | | Unit Count | 60.0 Count | ## Product Details - **Brand:** Life Extension - **Diet Type:** Vegetarian - **Flavor:** Unflavored - **Item Form:** Tablet - **Item Weight:** 3.52 ounces - **Item dimensions L x W x H:** 2.25 x 2.25 x 5 inches - **Primary Supplement Type:** S-Adenosyl-Methionine - **Product Benefits:** Helps maintain stable mood, Promotes liver health, Supports healthy joint function - **Special Ingredients:** S-Adenosyl-Methionine - **Unit Count:** 60.0 Count ## Images ![Life Extension Same, S-Adenosyl-Methionine, 400 mg, Mood and Liver Health and Joint Support Supplement, Non-GMO, Vegetarian, Gluten Free, 60 enteric-Coated Tablets - Image 1](https://m.media-amazon.com/images/I/71BRLIc8G5L.jpg) ![Life Extension Same, S-Adenosyl-Methionine, 400 mg, Mood and Liver Health and Joint Support Supplement, Non-GMO, Vegetarian, Gluten Free, 60 enteric-Coated Tablets - Image 2](https://m.media-amazon.com/images/I/81xSCMKDEwL.jpg) ![Life Extension Same, S-Adenosyl-Methionine, 400 mg, Mood and Liver Health and Joint Support Supplement, Non-GMO, Vegetarian, Gluten Free, 60 enteric-Coated Tablets - Image 3](https://m.media-amazon.com/images/I/81XJl01WsjL.jpg) ![Life Extension Same, S-Adenosyl-Methionine, 400 mg, Mood and Liver Health and Joint Support Supplement, Non-GMO, Vegetarian, Gluten Free, 60 enteric-Coated Tablets - Image 4](https://m.media-amazon.com/images/I/71nO1MHBb8L.jpg) ![Life Extension Same, S-Adenosyl-Methionine, 400 mg, Mood and Liver Health and Joint Support Supplement, Non-GMO, Vegetarian, Gluten Free, 60 enteric-Coated Tablets - Image 5](https://m.media-amazon.com/images/I/71F7Lc1q-8L.jpg) ## Questions & Answers **Q: What are SAMe supplements good for?** A: SAMe supplements benefit many critical metabolic functions in the body, help maintain a stable mood and support joint and liver health. **Q: How does SAMe support healthy joints?** A: SAMe supplements benefit many critical metabolic functions in the body, help maintain a stable mood and support joint and liver health. **Q: What do SAMe supplements do for your mood?** A: Research by the U.S. Department of Health and Human Services found that SAMe helps maintain a stable mood and healthy outlook. **Q: Can you take SAMe every day?** A: SAMe is safe to take every day according to the supplement label or the advice of your healthcare provider. These tablets are recommended one to three times daily to support a healthy mood. **Q: Should I take SAMe at night or morning?** A: It is suggested that these supplements are taken on an empty stomach or as recommended by a healthcare provider. ## Customer Reviews ### ⭐⭐⭐⭐⭐ Real Results - Ordered 11 More Boxes! *by S***A on November 12, 2025* The formula S-Adenosyl-Methionine (SAMe) is one of the most versatile and well-researched compounds. It participates in methylation processes that affect the nervous system, liver, and connective tissues. This dual action makes the formula unique: it supports emotional balance, helps restore cartilage, and improves joint flexibility. Each tablet is individually sealed in foil to prevent oxidation and maintain the stability of the active ingredient. This ensures the formula remains effective throughout its entire shelf life. The brand has long established itself as a reliable creator of thoughtfully developed supplements. Every product is marked by consistent quality and attention to detail, and this formula is an excellent example of their high standards. UPDATE - November 30, 2025: After just a week and a half, I noticed such significant changes that when I saw it was on sale, I immediately ordered 11 more boxes! I originally purchased this SAMe supplement only for joint support - my mood was fine, but I discovered it could be even better! I was surprised - not only did my joints feel much better, but my mood improved significantly as well. The dual-action formula truly works! Even starting with one tablet, I felt positive results. You can adjust the dosage based on your needs and how you feel. I take mine early in the morning on an empty stomach for best results. I’ve been using it for about a month now, and the results continue to impress me. The improvement in joint comfort is especially remarkable. If you’re considering this product, I highly recommend it. The results have been wonderful in every way - both for joint support and emotional well-being. Very happy with this purchase! ### ⭐⭐⭐⭐⭐ Very Helpful Product *by V***S on June 12, 2026* A long time ago my doctor told me to get this for depression. I've used it now for a long time and I won't change to other brands. ### ⭐⭐⭐⭐⭐ Helps me sleep *by D***N on June 3, 2026* I originally bought these because Gary Brecka recommended this for sleep. Ever since taking these I have noticed I sleep a lot better. The good news is I only had to take them for a few months and I noticed a big difference. Now I don't need to take them anymore. If I ever have trouble sleeping again I will take them. Just a tip: It does take a few weeks to actually notice a difference. They weren't magic and it took some time-- I did not notice right away. ## Frequently Bought Together - Life Extension Same 400mg (S-Adenosyl-Methionine) - Supplement for Joint & Liver Support - Non-GMO, Gluten-Free, Tablet, 60 Count - Life Extension Neuro-Mag Magnesium L-Threonate, Magnesium L-threonate, Memory Health, Quick Thinking, Cognitive Health Support, Vegetarian, Non-GMO, 90 Vegetarian Capsules - Life Extension TMG 500 mg – Trimethylglycine Supplement – Encourages Healthy Homocysteine Levels – Gluten-free – Non-gmo – Vegetarian – 60 Liquid Vegetarian Capsules --- ## Why Shop on Desertcart? - πŸ›’ **Trusted by 1.3+ Million Shoppers** β€” Serving international shoppers since 2016 - 🌍 **Shop Globally** β€” Access 737+ million products across 21 categories - πŸ’° **No Hidden Fees** β€” All customs, duties, and taxes included in the price - πŸ”„ **15-Day Free Returns** β€” Hassle-free returns (30 days for PRO members) - πŸ”’ **Secure Payments** β€” Trusted payment options with buyer protection - ⭐ **TrustPilot Rated 4.5/5** β€” Based on 8,000+ happy customer reviews **Shop now:** [https://www.desertcart.jp/products/74567161-life-extension-same-s-adenosyl-methionine-400-mg-mood-liver](https://www.desertcart.jp/products/74567161-life-extension-same-s-adenosyl-methionine-400-mg-mood-liver) --- *Product available on Desertcart Japan* *Store origin: JP* *Last updated: 2026-07-06*