---
product_id: 722673653
title: "Differin Acne Treatment Gel, 90 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 45g Pump"
brand: "differin"
price: "¥104"
currency: JPY
in_stock: false
reviews_count: 6
url: https://www.desertcart.jp/products/722673653-differin-acne-treatment-gel-90-day-supply-retinoid-treatment-face
store_origin: JP
region: Japan
---

# 90-day supply for lasting results Water-based, oil & fragrance free 0.1% Adapalene penetrates deep pores Differin Acne Treatment Gel, 90 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 45g Pump

**Brand:** differin
**Price:** ¥104
**Availability:** ❌ Out of Stock

## Summary

> ✨ Unlock flawless skin with science-backed retinoid power!

## Quick Answers

- **What is this?** Differin Acne Treatment Gel, 90 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 45g Pump by differin
- **How much does it cost?** ¥104 with free shipping
- **Is it available?** Currently out of stock
- **Where can I buy it?** [www.desertcart.jp](https://www.desertcart.jp/products/722673653-differin-acne-treatment-gel-90-day-supply-retinoid-treatment-face)

## Best For

- differin enthusiasts

## Why This Product

- Trusted differin brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Deep Pore Power:** Targets acne at the root for clearer skin
- • **Long-Term Clarity:** Clinically proven 87% fewer breakouts in 12 weeks
- • **Clean & Lightweight:** Oil-free, alcohol-free, fragrance-free formula that absorbs fast
- • **Gentle Yet Effective:** Formulated for sensitive, acne-prone skin without irritation
- • **Prevents Scarring & Hyperpigmentation:** Protects skin’s texture and tone while reducing marks

## Overview

Differin Acne Treatment Gel delivers prescription-strength 0.1% Adapalene retinoid in a gentle, water-based formula designed for sensitive, acne-prone skin. Clinically proven to reduce breakouts by up to 87% in 12 weeks, it works deep within pores to prevent acne formation, improve skin texture, and minimize scarring and hyperpigmentation. This 90-day supply pump offers a clean, non-comedogenic solution that fits seamlessly into your daily skincare routine.

## Description

Differin Gel contains an Rx-strength acne-fighting retinoid. It clears breakouts where they start (deep in the pores), Prevents acne before it begins, and as a result, restores skin's texture and tone.

Review: Dried my skin - I used it only for 3 days and it dried my skin so much that I had red patches. Stopped using immediately
Review: I’ve used Differin Gel on and off for years, and it’s consistently dependable in helping keep my skin clear and breakout-free. It’s gentle enough for sensitive, acne-prone skin yet effective in preventing clogged pores and future breakouts. I also like using it as part of my anti-aging routine. it’s a great alternative to tretinoin on days when I want something a little milder but still effective. The texture absorbs well without irritation or dryness when used correctly, and it layers nicely under moisturizer. For a 90-day supply, the price is absolutely worth it considering how well it maintains skin clarity and smoothness. Differin remains one of those reliable, science-backed products I always keep in my rotation for long-term skin health and maintenance.

## Features

- Clears breakouts where they start (Deep in pores) and prevents new acne from forming, which ultimately restores skin's texture and tone
- Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
- Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
- Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating Acne
- In a clinical study, Differin gel provided up to 87 percent reduction in acne breakouts after 12 weeks, which will continue to improve with further use

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B07ZTN5N1V |
| ASIN  | B07ZTN5N1V |
| Customer reviews | 4.6 4.6 out of 5 stars (9,376) |
| Date First Available  | 24 February 2020 |
| Department | Beauty & Personal Care |
| Department  | Beauty & Personal Care |
| Item model number | 0299.491040 |
| Item model number  | 0299.491040 |
| Manufacturer | Galderma |
| Manufacturer  | Galderma |
| Product Dimensions | 4.29 x 7.11 x 17.78 cm; 45 g |
| Product Dimensions  | 4.29 x 7.11 x 17.78 cm; 45 g |

## Product Details

- **Brand:** Differin
- **Item form:** 90 Day Supply
- **Product benefits:** acne prevention
- **Scent:** unscented
- **Skin type:** Sensitive

## Images

![Differin Acne Treatment Gel, 90 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 45g Pump - Image 1](https://m.media-amazon.com/images/I/61G3FDAnC8L.jpg)

## Questions & Answers

**Q: What are retinoids, and why are they important in clearing acne?**
A: Topical retinoids play a crucial role in the treatment of acne. Retinoids have vitamin A activity and help regulate skin cell turnover to make sure your skin goes through the process effectively, creating a healthier environment for skin.

**Q: Is Differin Gel dermatologist developed and tested?**
A: Yes, Differin Gel is dermatologist developed and includes a dermatologist-recommended retinoid.

**Q: How long does Differin Gel take to work?**
A: Differin Gel starts working immediately, and results may be seen in as little as two weeks. However, It may take up to 3 months to see significant results, but with continued use, it’s been proven to work, so hang in there.

**Q: Are there any side effects?**
A: Common side effects include dryness, redness, irritation, and burning/stinging, peaking at 2-4 weeks before improving. Not everyone experiences these, and in studies, most had mild symptoms.

**Q: If I experience irritation, should I discontinue use? What can I do to minimize skin irritation?**
A: Irritation is a common reaction that usually fades after 4 weeks. Use Differin Gel once daily and a gentle, non-comedogenic moisturizer. If symptoms persist or irritation becomes severe, discontinue use and consult your physician before reapplying.

## Customer Reviews

### ⭐ Dried my skin
*by J***. on 20 August 2022*

I used it only for 3 days and it dried my skin so much that I had red patches. Stopped using immediately

### ⭐⭐⭐⭐⭐ Review
*by P***A on 16 November 2025*

I’ve used Differin Gel on and off for years, and it’s consistently dependable in helping keep my skin clear and breakout-free. It’s gentle enough for sensitive, acne-prone skin yet effective in preventing clogged pores and future breakouts. I also like using it as part of my anti-aging routine. it’s a great alternative to tretinoin on days when I want something a little milder but still effective. The texture absorbs well without irritation or dryness when used correctly, and it layers nicely under moisturizer. For a 90-day supply, the price is absolutely worth it considering how well it maintains skin clarity and smoothness. Differin remains one of those reliable, science-backed products I always keep in my rotation for long-term skin health and maintenance.

### ⭐⭐⭐⭐⭐ Review
*by S***H on 6 January 2026*

I’ve been using Differin Acne Treatment Gel consistently, and it’s one of the most effective acne products I’ve tried, especially for long-term results. The 0.1% adapalene formula feels lightweight and spreads easily, and the pump packaging makes it simple to dispense the right amount without waste. What I appreciate most is how gentle it is compared to other retinoids. When I first started, I eased into it, and while there was some mild dryness, it was manageable and temporary. With regular use, my skin adjusted well, and I started noticing fewer breakouts and smoother texture overall. It doesn’t feel harsh or irritating when used properly, which is a big plus for sensitive or acne-prone skin. Over time, Differin has helped reduce clogged pores and the frequency of new breakouts. It’s not an overnight fix, but with patience and consistency, the results are real and noticeable. It layers well with moisturizer and doesn’t pill, making it easy to fit into a nighttime routine. Overall, this is a reliable, dermatologist-recommended acne treatment that delivers results without being overly aggressive. If you’re looking for a proven retinoid that works gradually and gently, Differin is a solid choice and well worth sticking with.

## Frequently Bought Together

- Differin Acne Treatment Gel, 90 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 45g Pump (Packaging May Vary)
- PanOxyl Acne Foaming Wash Benzoyl Peroxide 10% Maximum Strength Antimicrobial, 5.5 Oz
- Differin Acne Face Wash with 5% Benzoyl Peroxide, Daily Deep Cleanser by the makers of Differin Gel, Gentle Skin Care for Acne Prone Sensitive Skin, 4 oz (Packaging May Vary)

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*Product available on Desertcart Japan*
*Store origin: JP*
*Last updated: 2026-01-22*