---
product_id: 633650635
title: "Renue By Science Spermidine Supplements | Liposomal Spermidine Supplements for Women and Men | 90 Capsules - 8mg Spermidine per Serving | Non-GMO & Allergen Free | Made in The USA Third-Party Tested"
brand: "science"
price: "¥15724"
currency: JPY
in_stock: true
reviews_count: 8
category: "Renue By Science"
url: https://www.desertcart.jp/products/633650635-renue-by-science-spermidine-supplements-liposomal-spermidine-supplements-for-women
store_origin: JP
region: Japan
---

# Liposomal delivery for enhanced absorption Third-party tested, GMP certified 8mg Spermidine per serving Renue By Science Spermidine Supplements | Liposomal Spermidine Supplements for Women and Men | 90 Capsules - 8mg Spermidine per Serving | Non-GMO & Allergen Free | Made in The USA Third-Party Tested

**Brand:** science
**Price:** ¥15724
**Availability:** ✅ In Stock

## Summary

> 🧬 Elevate your cellular health—because aging gracefully is the new hustle!

## Quick Answers

- **What is this?** Renue By Science Spermidine Supplements | Liposomal Spermidine Supplements for Women and Men | 90 Capsules - 8mg Spermidine per Serving | Non-GMO & Allergen Free | Made in The USA Third-Party Tested by science
- **How much does it cost?** ¥15724 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.jp](https://www.desertcart.jp/products/633650635-renue-by-science-spermidine-supplements-liposomal-spermidine-supplements-for-women)

## Best For

- science enthusiasts

## Why This Product

- Trusted science brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Made in the USA:** Crafted in GMP-compliant facilities for uncompromising quality
- • **Inflammation Defense:** Lowers systemic inflammation while preserving vital NAD⁺ levels
- • **Next-Level Absorption:** Advanced liposomal technology ensures maximum bioavailability
- • **Clean & Trusted Formula:** Non-GMO, allergen-free, and rigorously third-party tested for purity
- • **Unlock Cellular Renewal:** Activates autophagy to clear damaged cells and boost longevity

## Overview

Renue By Science Spermidine Supplements deliver 8mg of spermidine per serving using a cutting-edge liposomal delivery system to maximize absorption. Designed to activate autophagy, reduce inflammation, and support healthy aging, this non-GMO, allergen-free formula is third-party tested and made in GMP-certified US facilities. Ideal for professionals seeking a scientifically backed edge in longevity and wellness.

## Description

Buy Renue By Science Spermidine Supplements | Liposomal Spermidine Supplements for Women and Men | 90 Capsules - 8mg Spermidine per Serving | Non-GMO & Allergen Free | Made in The USA Third-Party Tested on desertcart.com ✓ FREE SHIPPING on qualified orders

Review: Renue’s Spermidine producing real autophagy results! - I felt a definite rise in my energy and concentration levels after using Renue’s Spermidine for about 2 months! I’m definitely going to continue using it!
Review: Expensive spermidine supplement in liposomal format - Spermidine [SPD] is a natural polyamine derived from food uptake, production by intestinal microbiota, and cellular biosynthesis. Its presence varies among the species, cell types and tissues, as well as among foods of animal, fungi, or plant origin. Studies have shown that its cellular biosynthesis decreases with age in humans and animal models, and this might be a reflection of loss of microbial diversity in the gut. SPD is reported to play an important role in the regulation of nucleic acid, promoting cell growth, and inducing autophagy (that is, the natural degradation and recycling process of cells in multicellular organisms to remove unnecessary or dysfunctional cell components). It is claimed to provide multiple health benefits, but rather limited data are available on its supplementation benefits. A Japanese study, submitted in 2008 and published in 2009, was the first to report that SPD increases healthy lifespans in mice. An Austrian study, submitted and published in 2009, extended the finding to yeast, flies, worms, and in-vitro human cells -- an Austrian company formed around the latter study to commercialize its findings has been promoting the European trend of SPD as a dietary supplement since the mid 2010s, though much of the product nowadays comes from China. [1] Source. This is a private-label, encapsulated SPD extract (likely not from wheat germ as no zinc or vitamin B1 are listed as other ingredients) prepared in a liposomal format by an undisclosed foreign custom manufacturer. It is sourced by Renue by Science Inc, a CA online marketer with a virtual address (digital marketing agency) in FL, and sold here under its trademark. The long air pockets formed when the label was glued to the container I got (see arrows in my attached image) are not a reassurance of the quality of its manufacturer's operation. [2] Dosage. Each capsule contains 4 mg of SPD trihydrochloride. Safe dose amounts and limits have not yet been determined. At this time, only 5 pilot clinical trials in Germany or Austria have been completed and published, using dosages between 0.9 and 15 mg/day, which correspond to ~10% and ~170% respectively of the average SPD daily food intake in developed countries. In 2018, moderate memory improvement was reported in adults at risk for dementia taking 1.2 mg/day over 3 months. In 2021, another intervention trial in adults with moderate or mild dementia reported cognitive improvement with 3.3 mg/day of SPD over 3 months, but not with 1.9 mg/day. Then, in 2022, those authors of the 2018 work reported that reducing the SPD dosage to 0.9 mg/day did not show an effect after 12 months -- this reduction was selected to be below the SPD levels causing adverse effects in mice, and to placate concerns about the association of elevated polyamine levels and cancer (see Risks below). Finally, in 2023, a pharmacokinetics trial reported that 15 mg/day over 5 days increased spermine levels in plasma in a few healthy subjects, while those of SPD itself or putrescine were not affected. Obviously, more work is needed to determine proper dosage. Until then, though, the initial interventional results suggest that just ONE capsule (4 mg) of this brand per day should be sufficient to reach putatively effective blood levels with less potential risks than doubling the serving size (as proposed by the seller). [3] Risks. A significant (p=0.016) decrease of vitamin B12 concentration was found at the completion of the 2021 trial in the 3.3 mg/day group, but not the 1.9 mg/day group, suggesting that a medium dose of SPD induces a vitamin B12 decrease. Vitamins were not measured in the other trials, so such a result needs to be replicated. Further, it is a conflicting finding since B12-deficiency decreases SPD biosynthesis in rats and worms, as well as the lifespan of the latter. Just in case, consider taking SPD with a B12 supplement. Also of concern for the long-term user is the association of cancer with polyamines. They are essential for cell proliferation, and are found in high amounts in actively multiplying cancer cells. Recently, the reduction of polyamines levels by inhibiting their synthesis was found to be effective in some cancers. The association was important enough to reduce the SPD dosage in the cited 2022 trial. On the other hand, there are recent reports that SPD enhances antitumor responses (via its T-cell benefits) to immune checkpoint inhibitor therapy. Once more, there are conflicting findings on SPD positive vs. negative effects. [4] Cost. At the time of writing, this is the only 90-capsule, liposomal SPD brand on desertcart and, at $0.56 per count, it is rather more expensive than the other five liposomal-SPD brands also available here, even when their 60-capsule packs --typically more expensive than higher packs-- are considered ($0.33 to $0.37 per count). Naturally, non-liposomal SPD is even less expensive and more than likely to yield similar results. Be aware that there are no scientific reports of needing liposomal formulations for SPD bioavailability -- in fact, research in the mid-1990s already found that 87% to 96% of intragastrically-fed SPD to rats is available for uptake. --

## Features

- ACTIVATES AUTOPHAGY - Spermidine has the unique ability to activate autophagy, a powerful anti-aging process that helps clear out damaged or dysfunctional cellular components, promoting cellular health and longevity.*
- LOWERS INFLAMMATION & PRESERVES NAD⁺ - By activating autophagy, Spermidine helps lower systemic inflammation and preserve NAD⁺ levels, two key factors in the aging process.*
- SUPPORTS HEALTHY AGING - Spermidine has been studied for a range of health-protective effects that promote healthy aging and longevity, making it a valuable addition to your wellness routine.*
- ENHANCED BIOAVAILABILITY - Our advanced liposomal delivery system improves the bioavailability of Spermidine, ensuring better absorption and a slower release into the bloodstream for maximum efficacy.*
- QUALITY ASSURED - Spermidine (Liposomal) 90 Ct. is allergen-free, manufactured in a GMP compliant facility, and undergoes rigorous third-party testing to ensure the highest quality standards for your well-being.

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN  | B07JPY58XY |
| Best Sellers Rank | #91,046 in Health & Household ( See Top 100 in Health & Household ) #4,079 in Blended Vitamin & Mineral Supplements |
| Customer Reviews | 4.4 4.4 out of 5 stars (33) |
| Date First Available  | March 27, 2024 |
| Manufacturer  | Renue By Science |
| Package Dimensions  | 4.37 x 2.32 x 2.32 inches; 2.08 ounces |

## Product Details

- **Age Range (Description):** Adult
- **Brand:** Renue By Science
- **Dosage Form:** Capsule
- **Flavor:** Unflavored
- **Item Form:** Capsule
- **Number of Items:** 1
- **Package Information:** Bottle
- **Product Benefits:** Anti-Aging
- **Servings per Container:** 90
- **Unit Count:** 90 Count

## Images

![Renue By Science Spermidine Supplements | Liposomal Spermidine Supplements for Women and Men | 90 Capsules - 8mg Spermidine per Serving | Non-GMO & Allergen Free | Made in The USA Third-Party Tested - Image 1](https://m.media-amazon.com/images/I/518RUV17-GL.jpg)

## Customer Reviews

### ⭐⭐⭐⭐⭐ Renue’s Spermidine producing real autophagy results!
*by D***Y on October 14, 2025*

I felt a definite rise in my energy and concentration levels after using Renue’s Spermidine for about 2 months! I’m definitely going to continue using it!

### ⭐⭐⭐ Expensive spermidine supplement in liposomal format
*by A***E on June 24, 2024*

Spermidine [SPD] is a natural polyamine derived from food uptake, production by intestinal microbiota, and cellular biosynthesis. Its presence varies among the species, cell types and tissues, as well as among foods of animal, fungi, or plant origin. Studies have shown that its cellular biosynthesis decreases with age in humans and animal models, and this might be a reflection of loss of microbial diversity in the gut. SPD is reported to play an important role in the regulation of nucleic acid, promoting cell growth, and inducing autophagy (that is, the natural degradation and recycling process of cells in multicellular organisms to remove unnecessary or dysfunctional cell components). It is claimed to provide multiple health benefits, but rather limited data are available on its supplementation benefits. A Japanese study, submitted in 2008 and published in 2009, was the first to report that SPD increases healthy lifespans in mice. An Austrian study, submitted and published in 2009, extended the finding to yeast, flies, worms, and in-vitro human cells -- an Austrian company formed around the latter study to commercialize its findings has been promoting the European trend of SPD as a dietary supplement since the mid 2010s, though much of the product nowadays comes from China. [1] Source. This is a private-label, encapsulated SPD extract (likely not from wheat germ as no zinc or vitamin B1 are listed as other ingredients) prepared in a liposomal format by an undisclosed foreign custom manufacturer. It is sourced by Renue by Science Inc, a CA online marketer with a virtual address (digital marketing agency) in FL, and sold here under its trademark. The long air pockets formed when the label was glued to the container I got (see arrows in my attached image) are not a reassurance of the quality of its manufacturer's operation. [2] Dosage. Each capsule contains 4 mg of SPD trihydrochloride. Safe dose amounts and limits have not yet been determined. At this time, only 5 pilot clinical trials in Germany or Austria have been completed and published, using dosages between 0.9 and 15 mg/day, which correspond to ~10% and ~170% respectively of the average SPD daily food intake in developed countries. In 2018, moderate memory improvement was reported in adults at risk for dementia taking 1.2 mg/day over 3 months. In 2021, another intervention trial in adults with moderate or mild dementia reported cognitive improvement with 3.3 mg/day of SPD over 3 months, but not with 1.9 mg/day. Then, in 2022, those authors of the 2018 work reported that reducing the SPD dosage to 0.9 mg/day did not show an effect after 12 months -- this reduction was selected to be below the SPD levels causing adverse effects in mice, and to placate concerns about the association of elevated polyamine levels and cancer (see Risks below). Finally, in 2023, a pharmacokinetics trial reported that 15 mg/day over 5 days increased spermine levels in plasma in a few healthy subjects, while those of SPD itself or putrescine were not affected. Obviously, more work is needed to determine proper dosage. Until then, though, the initial interventional results suggest that just ONE capsule (4 mg) of this brand per day should be sufficient to reach putatively effective blood levels with less potential risks than doubling the serving size (as proposed by the seller). [3] Risks. A significant (p=0.016) decrease of vitamin B12 concentration was found at the completion of the 2021 trial in the 3.3 mg/day group, but not the 1.9 mg/day group, suggesting that a medium dose of SPD induces a vitamin B12 decrease. Vitamins were not measured in the other trials, so such a result needs to be replicated. Further, it is a conflicting finding since B12-deficiency decreases SPD biosynthesis in rats and worms, as well as the lifespan of the latter. Just in case, consider taking SPD with a B12 supplement. Also of concern for the long-term user is the association of cancer with polyamines. They are essential for cell proliferation, and are found in high amounts in actively multiplying cancer cells. Recently, the reduction of polyamines levels by inhibiting their synthesis was found to be effective in some cancers. The association was important enough to reduce the SPD dosage in the cited 2022 trial. On the other hand, there are recent reports that SPD enhances antitumor responses (via its T-cell benefits) to immune checkpoint inhibitor therapy. Once more, there are conflicting findings on SPD positive vs. negative effects. [4] Cost. At the time of writing, this is the only 90-capsule, liposomal SPD brand on Amazon and, at $0.56 per count, it is rather more expensive than the other five liposomal-SPD brands also available here, even when their 60-capsule packs --typically more expensive than higher packs-- are considered ($0.33 to $0.37 per count). Naturally, non-liposomal SPD is even less expensive and more than likely to yield similar results. Be aware that there are no scientific reports of needing liposomal formulations for SPD bioavailability -- in fact, research in the mid-1990s already found that 87% to 96% of intragastrically-fed SPD to rats is available for uptake. --

### ⭐⭐⭐⭐⭐ Love these!
*by S***E on February 11, 2025*

Great for energy!

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*Product available on Desertcart Japan*
*Store origin: JP*
*Last updated: 2026-02-01*