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✨ Unlock your skin’s future with science-powered glow!
Medicube Exosome Shot Zero 7,500 PPM Spicule Facial Serum is a cutting-edge skincare ampoule featuring micro-needle spicules infused with 15 million patented exosome shots. This advanced formula enhances absorption by 242%, delivering potent ingredients like niacinamide and panthenol deep into pores to refine texture, reduce pore size, and boost hydration. Clinically tested and gentle on all skin types, it offers a professional-grade treatment experience at home, perfect for millennials seeking radiant, youthful skin with a high-tech edge.

































| ASIN | B0D137TMRB |
| Best Sellers Rank | #225 in Beauty & Personal Care ( See Top 100 in Beauty & Personal Care ) #14 in Facial Serums |
| Brand | medicube |
| Brand Name | medicube |
| Customer Reviews | 4.5 out of 5 stars 5,638 Reviews |
| Item Form | Ampoule |
| Item Volume | 30 ml |
| Item Weight | 45 g |
| Manufacturer | Medicube |
| Manufacturer Part Number | PMEKR14040 |
| Model Number | 8809982768524 |
| Number of Items | 1 |
| Product Benefits | Pore Treatment |
| Recommended Uses For Product | Pore Care,Exfoliation,Improving Skin Texture |
| Scent | Aloe |
| Scent Name | Aloe |
| Skin Tone | All |
| Skin Type | Acne Prone, All, Combination, Dry, Sensitive |
| Special Ingredients | Alpha Hydroxy, Collagen, Minerals |
| Target Use Body Part | Face |
| Unit Count | 1.01 Fluid Ounces |
| Use for | Face |
H**S
Timeless beauty in a bottle
I purchased this product and it waz shipped out and delivered on time and with care. I used it right away and I want to give a detailed description about this item I received. I washed my face and I put a good amount on my face and it felt cool on the skin and right away you can feel it working. Rubbing it on the skin feels pretty good and than you start to feel a prickly feeling the more you work it into the skin, it doesn't hurt, it just feels like if you got fiberglass on the skin and you only feel that when touching the skin otherwise you wouldn't feel anything. A lil time went by and my skin started to get a slight sunburn look, it's exactly the same feeling as when you use dermaroller or stamp. It really is a needle less product and does the very same thing. Skin will feel warm cause blood is coming up to the skin which you want, to receive younger looking skin. It's plumping and the pores shrink and skin really looks amazing as it's working. The prickly feeling lasts throughout the night till next day and you wake up with a glow which feels good cause that's what we're looking for being age 53. I also added the medicube jelly collagen cream to give it an extra boost of hydration and adding the collagen it helps getting directly into the skin and the 2 together work wonders! This product helps us to deliver other products deeper into the skin so using the 2 is like a powerful regimen together! You will love the results. I used red light therapy to help as well and the 3 together makes the skin look amazing as well! It seems the more you touch your skin, the more you're allowing the product to work actively. Think of it as dermarolling and adding in serum as well as the red light therapy only the dermaroller has needles. I've used many products throughout time and dermaroller has given me the best results and these products here give exactly the same results only i love the outcome much better! I will continue using these products and highly recommend them to everyone who truly wants to get their glow back and look years younger in such a short time. My only regret is waiting to purchase these products but now I have them and plan on purchasing more. The night time mask is next. I compare this to frownies but much better due to me not ripping the patches from the skin and the mask is less invasive and works exactly the same, you're not missing any part of the skin when be able to apply it all over the face. I can't wait till I can update this after a couple of months of using these products. I had to explain in detail due to comments I've seen about how much it hurt cause it was the reason it took me longer to purchase this. It doesn't hurt and I hope you purchase it and try it cause I know you won't regret it at all. You'll be smiling cause as we age, our bodies change and I know I lost the natural glow i used to have and it's all back thanks to these products!! Thank you medicube for amazing products!! You have a lifetime customer here and with my skin only getting younger, I hope I can be someone that can help others to achieve the look we're all looking for at this age. I have and id love to see others look in the mirror and say wow! I like who I'm looking at😉
C**A
Ingredients That Work
Let me just start by saying—WOW. The Medicube Zero Exosome Shot isn’t just a serum; it’s a whole experience for your skin. This powerhouse product contains 7,500 PPM of spicules (microneedle-like ingredients derived from marine sponges) infused with exosomes—tiny messengers that help regenerate skin and deliver active ingredients deeper than ever before. Translation? It’s like giving your skin a professional-grade treatment right at home or in between spa sessions. The serum has a lightweight, milky consistency that absorbs beautifully. The spicules give a slight tingling sensation, almost like tiny little needles, which lets you know it’s working. It might feel intense to sensitive skin types, but the payoff is worth it. After just a few uses, my skin looked noticeably smoother, brighter, and more refined. It’s excellent for targeting large pores, dullness, and even fine lines. I noticed a more even tone and an overall glow—yes, that “glass skin” vibe! This formula includes not only exosomes but niacinamide and peptides, which work together to firm, brighten, and boost your skin barrier. If you’re serious about anti-aging and skin rejuvenation, this one deserves a spot in your routine. I love pairing this with a cooling jelly mask after use to calm the skin while letting all the goodness soak in. It’s a great post-facial booster or a weekly treatment if you’re doing self-care from home. I give the Medicube Zero Exosome Shot a solid 10/10. It’s clinical-grade care in a bottle—and perfect for anyone who wants results with a bit of spice. (Not pain—but definitely a tingle!) Just remember to moisturize well afterward and always wear your SPF, beauties.
L**A
7500 & No pain, love this light serum, doesn’t pill and I used shot mode first & booster mode with
This is a great serum, I was kind of afraid of trying it at first since I bought the higher level version at 7500 and reading reviews saying that it hurt to put on but once I did try it I was very happily surprised. My skin had a glow to it after application and there was no pain when applying. I rubbed it on my face, cheek to check then forehead then patted it on my face to absorb better and it was more like a very light tingly feeling but only when I patted the spot I was applying the serum to. This isn’t sticky on my skin, there isn’t a scent to it and it’s not painful, it’s also very light weight and comes out of the pump looking like a thin see though gel looking serum so this is one I use first before my pdrn collagen serum or any of my other Medicube serums because this EXO serum seems to be the lightest and very helpful to your skin and pores. This 7500 EXO feels very hydrating as well, I put it on and took a nap and when I woke it felt like a moisturizer on my face but didn’t rub of onto my pillows as it went into my skin, I touched my face and could still feel the very light tingle ( I can’t think of a different name then tingle but it’s more like when you pat or rub it into your face you can feel a light sensation on you face, it’s quite pleasant though.) I am so glad I didn’t purchase the 2000 version because the 7500 it just perfect. You can feel it’s on your face but no pain, I also made sure to use the booster pro age-r on shot mode and used the pore toner pads before. I have sensitive skin and this didn’t bother my face but if you have extremely sensitive skin then maybe try the 2000 first. It really depends on your skin. Personally I wouldn’t waste on the 2000 and just buy the 7500 because it is so light feeling even though you can still feel it, it kinda feels nice when applying. This doesn’t pill on your face if you want to use the booster mode after or apply another serum over it. I used the salmon pdrn serum on booster mode after I waited about 30 minutes for the pore shot serum to dry, I then used the booster mode after for the pore shot by putting it on level 2 and moving it up towards my forehead and still no pain,. Then used the salmon pdrn serum ( highly recommend! ) over it, finishing the 5 min for booster mode and had a lovely glow with pink cheeks. I wish I tried this exosome spicule shot a long time ago, it’s lovely and not painful but you can feel and tell it’s working on your face. I finished with the cooling jelly moisturizer and a collagen liquid mask once the 2 ( patted on my face by hand ) layers of moisturizer had dried. The next day my face felt and looked great with a nice glow to it and a glasssy finish which I absolutely love about the Medicube products, they due all work and makes your face look younger, also helps get rid of fine lines. This serum is an amazing product to start with after applying the toner pad and if you have a shot mode appliance by Medicube make sure to due that first ( before toner ) because it opens your pores and helps the serum penetrate deeper as does the booster mode, it helps your products go deeper into your skin and also helps the serums dry faster as they penetrate your skin deeper, saves time when you’re doing your night routine and is now a staple for me each night. Great skincare products! I love Medicube products and they actually work as well at a great price point compared to other brands. I always update my reviews if something changes, so if my opinion changes about this product I will be updating. For now I can’t wait to try the salmon pdrn EXO shot next!
B**Y
Already seeing results. Tracking photos to add later!
My goodness. I didn't know what to expect with this. Decided to start out with the 7500 PPM Spicule Facial Serum. It doesn't mess around. It isn't terrible --- but --- it does give a stinging/prickling sensation as you rub, but only as you're rubbing it on your face. That goes away as soon as you stop contact with your skin. With my experience with the application of this, there's a good possibility that people with the really angry, red skin could have rubbed their face for way too long with this stuff. Could be extremely sensitive skin, also. My advice, for what it's worth, would be to ease into this carefully. If you have really sensitive skin, then do a test patch. If you have no issues, then go to town on your face with it. LOL The closest comparison I can come up with is feeling like rubbing fiberglass over your face. I use in the evening before bed. On my clean, damp face, I'll apply this product. Then add a blend of Helios & Nebula serums from Earth Harbor to moisturize before I sleep for the night. I use the palm method: Combine 2–3 drops of Helios and 2–3 drops of Nebula directly into the palm of your hand, mix them with your fingertips, and press into clean skin Helios (Yellow/Orange): Focuses on repairing the skin barrier, protecting against pollution, and providing antioxidant-rich anti-aging benefits using astaxanthin and plant stem cells. Nebula (Black): Focuses on calming inflammation, balancing oil production, and clearing pores using adaptogens and sea lavender. Combined: This blend is excellent for protecting and repairing your skin barrier while simultaneously calming irritation and preventing congestion.
A**R
Nice addition to skincare routine
Like the tingling feel and seems to be shrinking pores. Good results for price.
F**J
MOST EFFECTIVE SERUM ON THE MARKET
This serum has left me speechless!! Everytime I put this on I wake up glowing!! It literally will transform your skin over night!! This serum leaves your skin soft, your pores small, and helps even skin tone after consist use!! It is very lightweight and it does tingling but it does not hurt!! I love Medicube! Buy it !!
J**S
7,500ppm SENSITIVE SKIN - Positive Results, Full Notes
Ok I purchased 2x of these ~6mos ago and here’s my experience: Version: 7.5k ppm Age: 35 Skin type: sensitive, dry Skin concerns: early aging - wrinkles, sun damage, loss of collagen in forehead and under eye causing very dark circles Use: Initially 2x/week, then upped to 3-4x for 3 mos, now in a 1x maintenance Firstly yall, these will cause trauma to the skin, the spicules (tiny needles) penetrate skin to cause damage, stimulating collagen renewal and allowing product to soak in better. What this means: - DO NOT use this product unless your skin and your hands are CLEAN. It will cause allergic reactions, inflammation, etc. - if you have sensitive skin, be sure you have used any following products (retinols, txa serums, etc) previously with no reaction. Do not test new products when using this (😣) - the 7.5k ppm reedle serum WILL be more than just a “tingle” - it’s going to be a little uncomfy just like microneedling. You can also overdo the rubbing in - I did early on and my whole face was blazing red and hot for over an hour. When I tried applying with less rubbing later, it was much more manageable. My skincare regime is in the attached photo - I rotate the 3 moisturizers as needed. The 345 relief cream is AMAZING next day. Results: better collagen coverage of dark circles, forehead skin is markedly less thin, cheeks bouncier! Did not do much for my skin damage (freckles), but I also realized that the spf I was using was garbage so that was an uphill battle. I will absolutely do this cyclically 2x a year to keep my skin improving over time. I consulted with an aesthetician and she said they absolutely recommend this as a stand in for microneedling on a budget. Final notes - I really enjoyed this product and saw real results. I am swapping to VT reedle shot 700 or 1000 though as it has really incredible ingredients - ceramides and amino acids, shea, macadamia nut oil, ginseng, etc.
J**G
Fantastic results!
It works so well! Definitely Spicy! My first impression had me feeling like I was rubbing tiny glass shards into my skin lol It was tolerable though! My face looked sunburnt for about an hour, skin felt hot, and slightly itchy (not real bad), then gradually it went away. AGAIN TOLERABLE! I paired it with the medicube zero pore pads and the pdrn serum. MY FACE LOOKS FANTASTIC AFTER JUST ONE USE. I have acne scars on my face, and they are damn near GONE and my pores look nonexistent. I was thoroughly shocked when I looked in the mirror. BESTIE DONT HESITATE! This is a permanent addition to my routine now!
R**A
Almost immediate results
Though the needle tingling lasts a while, yet u feel almost immediate results! Just use a good moisturizer afterwards. Amazing!
T**E
Ça pique
Me convient bien pour l'instant. J'attends de voir les résultats sur la durée. Ça pique fort quand même.
B**N
Das ideaal voor al huid
Geweldig
S**N
Excellent
..
O**I
Super!
Produkte von Medicube benutze ich schon seit 2 Jahren. Gute Qualität und sichtbare Ergebnisse. Ich bin sehr zufrieden! Vor paar Monaten habe ich den Medicube Store in Seoul (Seongsu) besucht🥰 Ich finde es toll, dass man in Deutschland einige Produkte vom Sortiment kaufen kann.
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