---
product_id: 543984741
title: "Isdinceutics Retinal Advanced - Rejuvenating Facial Night Serum with Retinaldehyde and Melatonin 1.7 FL OZ (50 ml)"
brand: "isdin"
price: "¥57039"
currency: JPY
in_stock: true
reviews_count: 8
category: "Isdin"
url: https://www.desertcart.jp/products/543984741-isdinceutics-retinal-advanced-rejuvenating-facial-night-serum-with-retinaldehyde-melatonin
store_origin: JP
region: Japan
---

# Clinically proven -43% wrinkles in 4 weeks Night serum with retinaldehyde + melatonin Dual-phase tech for ingredient stability Isdinceutics Retinal Advanced - Rejuvenating Facial Night Serum with Retinaldehyde and Melatonin 1.7 FL OZ (50 ml)

**Brand:** isdin
**Price:** ¥57039
**Availability:** ✅ In Stock

## Summary

> 🌟 Wake up to younger, glowing skin — your nightly glow-up essential!

## Quick Answers

- **What is this?** Isdinceutics Retinal Advanced - Rejuvenating Facial Night Serum with Retinaldehyde and Melatonin 1.7 FL OZ (50 ml) by isdin
- **How much does it cost?** ¥57039 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.jp](https://www.desertcart.jp/products/543984741-isdinceutics-retinal-advanced-rejuvenating-facial-night-serum-with-retinaldehyde-melatonin)

## Best For

- isdin enthusiasts

## Why This Product

- Trusted isdin brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Hydrating Nighttime Ritual:** Melatonin-infused serum nourishes and rejuvenates skin overnight for a radiant morning glow.
- • **Gentle Yet Powerful Retinal:** Retinaldehyde, a potent retinoid, smooths skin texture while being suitable for sensitive skin types.
- • **Universal Skin Compatibility:** Tested and proven effective for all skin types, including sensitive and dry skin, minimizing irritation risk.
- • **Advanced Dual-Phase Stability:** Innovative two-phase formula ensures maximum potency and freshness of active ingredients every night.
- • **Clinically Validated Youth Boost:** Clinically shown to reduce wrinkles by 43% in just 4 weeks, delivering visible age-defying results.

## Overview

ISDIN Isdinceutics Retinal Advanced is a scientifically formulated night serum combining retinaldehyde and melatonin in a dual-phase system to visibly reduce wrinkles by 43% within 4 weeks. Designed for all skin types, including sensitive skin, it smooths texture, boosts radiance, and enhances skin firmness while maintaining ingredient stability for maximum effectiveness.

## Description

desertcart.com: ISDIN Isdinceutics Retinal Advanced - Rejuvenating Facial Night Serum with Retinaldehyde and Melatonin 1.7 FL OZ (50 ml) : Beauty & Personal Care

Review: I love it - Value for money, effectiveness, excellent texture.
Review: First Retinoid Product - so far so good! - I’ve never used retinal/retinol etc, so using this product is my very first attempt. I am 40+, fair skin, sensitive skin, dry skin, med/large pores, still prone to hormonal breakouts, some sun damage freckling, pretty deep 11s, and very minor wrinkles anywhere else. I started using this right around 2/1/24. It’s now 2 months of almost nightly use since (I’ve skipped a couple nights here or there just from schedule issues). I do use a full 2 pumps each time, every night, and I run the excess down my neck and upper chest to help with signs of aging there. I thought FOR SURE I would have bad peeling, redness, etc because I have sensitive skin and usually EVERYTHING makes me red or break out. But this hansy been bad at all! I started to think that might mean it’s a dud product, but I have been going thru “purge” for about 3-4 weeks. Not constant, but a couple of rounds of very agitated pimples. Moreso than I usually get, and I am used to have them every month with my cycle. So that makes me feel like it’s doing SOMETHING! I think I may be on the downward slope of the purge…. Hopefully. How does my skin feel or look? Well, it actually does feel more hydrated and softer than ever. I love that! It looks slightly more even tone (between the breakout areas when I’m having pimples and generally all over when I’m not having a breakout.) I also feel like I’m seeing a little more radiance or glow. Nothing miraculous, but just a little more shine and luster. I have not noticed a reduction in my deep 11s or my 2 very fine forehead lines. So far I’m happy. It’s such an expensive product I hate that you have to spend so much to find out if it works, but I feel like the signs I’m seeing now support continued use and expense. At 2 months, it looks to me like I might have 1 month of product left in the jar. For the price I paid, if it lasts 3 months, that’s about $62 a month ($744 a year!). I’ve never had an rx from a derm, so I’m not sure how that compares to prescription and office visit costs. I’m going to continue trying this for the full year. If I feel confident that I’m seeing results, I’ll do a cost comparison of actually getting on and maintaining a retinoid rx or just continuing this product. Will update!

## Features

- YOUR SOLUTION FOR: Fine lines and wrinkles, loss of elasticity and firmness, dullness
- KEY INGREDIENT: A very effective retinoid, retinaldehyde demonstrates powerful youth-boosting properties
- ACTION: Smoothes skin texture for visibly younger-looking skin
- TESTED: Advanced formula tested for all skin types, including sensitive skin
- TECHNOLOGY: Separates ingredients into two phases to keep formula stable and effective
- RESULTS: Clinical results show -43% of wrinkles after 4 weeks

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B0CC9W3VWR |
| Age Range (Description) | Adult |
| Age Range Description | Adult |
| Best Sellers Rank | #53,552 in Beauty & Personal Care ( See Top 100 in Beauty & Personal Care ) #1,095 in Facial Serums |
| Brand | ISDIN |
| Brand Name | ISDIN |
| Customer Reviews | 4.5 out of 5 stars 185 Reviews |
| Item Form | Cream |
| Item Volume | 1.7 Fluid Ounces |
| Manufacturer | ISDIN |
| Number of Items | 1 |
| Product Benefits | Retinal Advanced is a night serum that helps visibly reduce wrinkles and fine lines. Formulated with youth-boosting ingredients such as retinaldehyde, it helps smooth and rejuvenate the skin. |
| Recommended Uses For Product | Wrinkles |
| Skin Type | All |
| Special Ingredients | vitamin_e |
| Specific Uses For Product | Apply at night onto clean, dry skin. Press pump twice to dispense the right amount into hand, mix well, and apply. Always apply a broad spectrum sunscreen the next morning and throughout the day. |
| Target Use Body Part | Skin |
| Unit Count | 1.7 Fluid Ounces |

## Product Details

- **Age Range (Description):** Adult
- **Brand:** ISDIN
- **Item Volume:** 1.7 Fluid Ounces
- **Number of Items:** 1
- **Skin Type:** All

## Images

![Isdinceutics Retinal Advanced - Rejuvenating Facial Night Serum with Retinaldehyde and Melatonin 1.7 FL OZ (50 ml) - Image 1](https://m.media-amazon.com/images/I/51pcEQVydwL.jpg)

## Questions & Answers

**Q: Is Retinal Advanced suitable for sensitive skin?**
A: Yes! It’s suitable for all skin types. Retinal Advanced has been clinically tested on a wide range of skin types, including sensitive skin

**Q: Can I use it day and night?**
A: The use of retinoids can make the skin more sensitive to external factors, meaning that the effect of sun exposure can be more intense. For this reason, we recommend using it at night, followed by a broad spectrum sunscreen in the morning.

**Q: Can I use it at any time of the year?**
A: Yes, once your skin is retinized, you can use Retinal Advanced at night all year round. No matter the time of year: always apply sun protection the next morning!

## Customer Reviews

### ⭐⭐⭐⭐⭐ I love it
*by M***E on January 29, 2026*

Value for money, effectiveness, excellent texture.

### ⭐⭐⭐⭐⭐ First Retinoid Product - so far so good!
*by R***B on April 6, 2024*

I’ve never used retinal/retinol etc, so using this product is my very first attempt. I am 40+, fair skin, sensitive skin, dry skin, med/large pores, still prone to hormonal breakouts, some sun damage freckling, pretty deep 11s, and very minor wrinkles anywhere else. I started using this right around 2/1/24. It’s now 2 months of almost nightly use since (I’ve skipped a couple nights here or there just from schedule issues). I do use a full 2 pumps each time, every night, and I run the excess down my neck and upper chest to help with signs of aging there. I thought FOR SURE I would have bad peeling, redness, etc because I have sensitive skin and usually EVERYTHING makes me red or break out. But this hansy been bad at all! I started to think that might mean it’s a dud product, but I have been going thru “purge” for about 3-4 weeks. Not constant, but a couple of rounds of very agitated pimples. Moreso than I usually get, and I am used to have them every month with my cycle. So that makes me feel like it’s doing SOMETHING! I think I may be on the downward slope of the purge…. Hopefully. How does my skin feel or look? Well, it actually does feel more hydrated and softer than ever. I love that! It looks slightly more even tone (between the breakout areas when I’m having pimples and generally all over when I’m not having a breakout.) I also feel like I’m seeing a little more radiance or glow. Nothing miraculous, but just a little more shine and luster. I have not noticed a reduction in my deep 11s or my 2 very fine forehead lines. So far I’m happy. It’s such an expensive product I hate that you have to spend so much to find out if it works, but I feel like the signs I’m seeing now support continued use and expense. At 2 months, it looks to me like I might have 1 month of product left in the jar. For the price I paid, if it lasts 3 months, that’s about $62 a month ($744 a year!). I’ve never had an rx from a derm, so I’m not sure how that compares to prescription and office visit costs. I’m going to continue trying this for the full year. If I feel confident that I’m seeing results, I’ll do a cost comparison of actually getting on and maintaining a retinoid rx or just continuing this product. Will update!

### ⭐⭐⭐⭐⭐ Excellent retinol
*by K***T on October 13, 2025*

Looooooove what this ISDIN retinol does to my skin. I purchased it originally from a pharmacy overseas as a recommendation from the pharmacist. I wanted to have smoother skin. I purchased it again off Amazon when I ran out. Great product! Just a pea size amount at night and moisturizer afterwards.

## Frequently Bought Together

- ISDIN Isdinceutics Retinal Advanced - Rejuvenating Facial Night Serum with Retinaldehyde and Melatonin 1.7 FL OZ (50 ml)
- ISDIN Eryfotona Actinica Zinc Oxide and 100% Mineral Sunscreen Broad Spectrum SPF 50+, No White Cast, Suitable for Sensitive Skin
- Vitamin C and Hyaluronic Acid Serum ampoule, Flavo-C Ultraglican by ISDIN

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*Product available on Desertcart Japan*
*Store origin: JP*
*Last updated: 2026-02-15*