---
product_id: 530540970
title: "PREMIO, Sangi's Nano-Hydroxyapatite Toothpaste for Naturally Whiter Teeth, No Fluoride, For family use, 105g / 3.7 Oz, Double Mint, Pack of 2"
brand: "apagard"
price: "¥9556"
currency: JPY
in_stock: true
reviews_count: 13
category: "Apagard"
url: https://www.desertcart.jp/products/530540970-premio-sangis-nano-hydroxyapatite-toothpaste-for-naturally-whiter-teeth-no
store_origin: JP
region: Japan
---

# Double mint flavor, fresh breath Fluoride-free, natural formula Nano-Hydroxyapatite for enamel repair PREMIO, Sangi's Nano-Hydroxyapatite Toothpaste for Naturally Whiter Teeth, No Fluoride, For family use, 105g / 3.7 Oz, Double Mint, Pack of 2

**Brand:** apagard
**Price:** ¥9556
**Availability:** ✅ In Stock

## Summary

> 🦷 Elevate your smile game with Japan’s best-kept secret!

## Quick Answers

- **What is this?** PREMIO, Sangi's Nano-Hydroxyapatite Toothpaste for Naturally Whiter Teeth, No Fluoride, For family use, 105g / 3.7 Oz, Double Mint, Pack of 2 by apagard
- **How much does it cost?** ¥9556 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.jp](https://www.desertcart.jp/products/530540970-premio-sangis-nano-hydroxyapatite-toothpaste-for-naturally-whiter-teeth-no)

## Best For

- apagard enthusiasts

## Why This Product

- Trusted apagard brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Long-Lasting Freshness:** Double mint flavor delivers a refreshing, balanced taste without overpowering your senses.
- • **Daily Defense & Whitening:** Use thrice daily to remove plaque, prevent sensitivity, and reveal naturally brighter teeth.
- • **Fluoride-Free & Family Safe:** A clean, chemical-conscious choice perfect for all ages and sensitive teeth.
- • **Revolutionary Nano-Hydroxyapatite:** Mimics natural tooth enamel to gently restore and whiten your smile.
- • **Clinically Trusted Japanese Innovation:** Backed by decades of research, Japan’s top toothpaste brand now in the US.

## Overview

APAGARD® PREMIO is a fluoride-free toothpaste featuring Sangi’s patented nano-hydroxyapatite, a biomimetic mineral that repairs and whitens teeth naturally. Originating from Japan’s leading oral care research, this double mint formula offers gentle yet effective plaque removal, breath care, and enamel restoration, making it ideal for family use and daily whitening without harsh chemicals.

## Description

Ingredients (INCI name): AQUA, DICALCIUM PHOSPHATE, GLYCERIN, HYDROXYAPATITE, SILICA, PEG-8, SODIUM LAURYL SULFATE, CELLULOSE GUM, AROMA, TRIMAGNESIUM PHOSPHATE, HYDROLYZED CONCHIOLIN PROTEIN, SODIUM SACCHARIN, GLYCYRRHETINIC ACID, CETYLPYRIDINIUM CHLORIDE, LAURYL IETHYLENEDIAMINOGLYCINE HCL

Review: Best kept secret regarding toothpaste….. - I read an article several years ago about hydroxyapatite toothpaste, and gave it a try. I will never go back, and have been so pleased with the appearance and feel of my teeth in my mouth. I have tried many different brands during this time, and this brand really stood out to me, with its pleasant taste, excellent cleaning, and great mouth feel. In all fairness, there are many other great brands available, which are also very good. Since finding this new type of toothpaste, I have to question why it is not available mainstream in the US, and advertised. My dentist asked me if I was using a teeth whitening product, and didn’t seem very welcoming, when I shared what I was using. This product, cleans, whitens, and works to prevent teeth sensitivity. Excellent product.
Review: Clean minty taste, but not too strong. Does a good job. No fluoride - Has a clean minty taste. I bought it because it is fluoride free and the hydroxyapatite is supposed to be really good for your teeth Its a smooth paste, there isn't any grit. It made my teeth feel polished (I brush with an electric toothbrush and do the whole 2 minutes, clean each individual tooth routine). I like that the taste isnt overwhelming at all. Some mint toothpaste can be very overwhelming! I received 2 tubes and I think the price is fair, considering no fluoride and it still protects your teeth

## Features

- APAGARD, Japan's leading toothpaste series for naturally beautiful teeth, is now available in the US. Discover the secret of naturally beautiful teeth from Japan. Contains Sangi's original nano-hydroxyaptite (nano-mHAP), almost the same substance as the hydroxyapatite that our teeth are made of, first synthesized in the 1970s by Sangi Co., Ltd
- APAGARD cleans the teeth and helps remove plaque with regular brushing.
- APAGARD M-plus is the standard, classic version and longest-selling product in the APAGARD range. It offers an all-around balance between natural whiteness enhancement, breath care, and stain control, and is suited for all ages, coming in a higher volume package, ideal for family use.
- For the best effect from nano-mHAP toothpaste, we recommend that you (1) Place a small amount (1-1.5 cm) on a toothbrush. (2) Brush your teeth and gums gently but meticulously for about 3-5 minutes, ideally after each meal (3 times/day is recommended) (3) Rinse lightly and spit out after brushing, so nano-mHAP remaining will enrich your saliva and continue its work.

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN  | B0C379SKGN |
| Best Sellers Rank | #9,371 in Health & Household ( See Top 100 in Health & Household ) #187 in Toothpaste |
| Customer Reviews | 4.6 4.6 out of 5 stars (1,189) |
| Date First Available  | April 23, 2023 |
| Item model number  | 4987643122183 |
| Manufacturer  | SANGI Co., Ltd. |

## Product Details

- **Age Range (Description):** Adult
- **Brand:** APAGARD
- **Flavor:** Unflavored
- **Item Form:** Paste
- **Material Type Free:** Fluoride Free

## Images

![PREMIO, Sangi's Nano-Hydroxyapatite Toothpaste for Naturally Whiter Teeth, No Fluoride, For family use, 105g / 3.7 Oz, Double Mint, Pack of 2 - Image 1](https://m.media-amazon.com/images/I/61eDwvzPDGL.jpg)

## Questions & Answers

**Q: Complete list of ingredients?**
A: Google "Premio Apagard ingredients", it's in English on several websites. It's also in Japanese and English on the product box, just not on the tube itself.

**Q: Still flouride free?**
A: Fluoride is not listed as an ingredient on the outside of the box that the tube is shipped in. An additional label in English is pasted over the Japanese, I suppose for when the product is shipped to an English-speaking country.

**Q: Does this toothpaste have an expiration in storage?**
A: The shelf life of Apagard Premio toothpaste is two years.

**Q: What is the percentage of Nano Hydroxyapatite? And what is the flavor?**
A: Apagard uses 10% and 15%, depending on the toothpaste. But that's not total % of the toothpaste in the tube. That suspension is added to the toothpaste. Boka uses a 15.5% suspension, and the total amount is 2% of the toothpaste.  The flavor of the toothpaste is a very light mint.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Best kept secret regarding toothpaste…..
*by W***S on September 7, 2025*

I read an article several years ago about hydroxyapatite toothpaste, and gave it a try. I will never go back, and have been so pleased with the appearance and feel of my teeth in my mouth. I have tried many different brands during this time, and this brand really stood out to me, with its pleasant taste, excellent cleaning, and great mouth feel. In all fairness, there are many other great brands available, which are also very good. Since finding this new type of toothpaste, I have to question why it is not available mainstream in the US, and advertised. My dentist asked me if I was using a teeth whitening product, and didn’t seem very welcoming, when I shared what I was using. This product, cleans, whitens, and works to prevent teeth sensitivity. Excellent product.

### ⭐⭐⭐⭐⭐ Clean minty taste, but not too strong. Does a good job. No fluoride
*by A***S on January 25, 2026*

Has a clean minty taste. I bought it because it is fluoride free and the hydroxyapatite is supposed to be really good for your teeth Its a smooth paste, there isn't any grit. It made my teeth feel polished (I brush with an electric toothbrush and do the whole 2 minutes, clean each individual tooth routine). I like that the taste isnt overwhelming at all. Some mint toothpaste can be very overwhelming! I received 2 tubes and I think the price is fair, considering no fluoride and it still protects your teeth

### ⭐⭐⭐⭐⭐ Visible results quickly
*by C***A on June 15, 2025*

This product produced visible results within days of starting it. I dislike going to the dentist and was dealing with sensitivity from receding gums due to age. I was hoping to stop the recession as well as the sensitivity. Within days I noticed my teeth were cleaner of tartar; much whiter and a reduction in sensitivity. Plus this toothpaste, unlike many others, leaves your mouth with an wonderful clean feeling. The mint taste is good, fresh and light and lasts a long time after brushing. I haven't yet noticed any change in my gum recession, but I hope given time it will stop it. I love that it doesn't contain any fluoride. Yes, it's a bit expensive but worth it in my opinion. You don't need to use much to get results. I brush more than 4 times a day. I highly recommend this.

## Frequently Bought Together

- APAGARD® PREMIO, Sangi's Nano-Hydroxyapatite Toothpaste for Naturally Whiter Teeth, No Fluoride, For family use, 105g / 3.7 Oz, Double Mint, Pack of 2
- Boka Fluoride Free Toothpaste Nano Hydroxyapatite, Helps Remineralize, Appropriate for Sensitive Teeth, Whitening - for Adult, Kids Oral Care - Refresh Mint Flavor, 4 Fl Oz 1Pk
- Apagard Tooth Polish Royal 135g toothpaste, Direct from Japan

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*Product available on Desertcart Japan*
*Store origin: JP*
*Last updated: 2026-02-06*