








🛡️ Keep your best friend itch-free and unstoppable all month long!
FRONTLINE Plus for Dogs (Extra Large, 89-132 lbs.) is a vet-trusted, waterproof topical treatment that kills fleas, flea eggs, larvae, chewing lice, and ticks—including those that transmit Lyme disease. With a single monthly dose, it provides continuous protection by depositing active ingredients in the skin’s sebaceous glands, ensuring fast-acting and long-lasting defense. Suitable for dogs as young as 8 weeks and weighing 5 pounds or more, this 6-dose pack offers hassle-free, proven flea and tick control trusted by pet owners for over two decades.













| ASIN | B0002J1FPI |
| ASIN | B0002J1FPI |
| Age Range Description | All Life Stages |
| Best Sellers Rank | #2,944 in Pet Supplies ( See Top 100 in Pet Supplies ) #12 in Dog Flea Drops |
| Brand Name | Frontline |
| Breed Recommendation | Large Breeds |
| Care Instructions | Keep away from Children |
| Color | Red Box |
| Country of Origin | United States |
| Customer Reviews | 4.4 4.4 out of 5 stars (15,114) |
| Date First Available | August 3, 2004 |
| Date First Available | August 3, 2004 |
| Department | Pet Supplies |
| Department | Pet Supplies |
| Directions | Directions for Use Step 1. To REMOVE Applicator: 1. Use scissors to separate one blister; 2. Use scissors to cut along dotted line; 3. Peel down foil to remove the applicator. Step 2. OPEN Applicator. Hold upright with foil side toward you and snap applicator tip. Step 3. APPLY FRONTLINE Plus. Part the dog’s hair between the shoulder blades. Place the applicator tip just above the skin and squeeze… |
| Included Components | Package includes 6 applicators |
| Is Discontinued By Manufacturer | No |
| Item Dimensions LxWxH | 2 x 5.4 x 0.15 inches |
| Item Package Dimensions L x W x H | 5.83 x 4.37 x 1.06 inches |
| Item Weight | 0.15 Pounds |
| Item model number | 72220 |
| Item model number | 72220 |
| Manufacturer | Boehringer Ingelheim Animal Health |
| Manufacturer | Boehringer Ingelheim Animal Health |
| Model Name | Frontline Plus for Dogs Extra Large Dog (89 to 132 pounds) Flea and Tick Treatment, 6 Doses |
| Number of Items | 6 |
| Product Dimensions | 2 x 5.4 x 0.15 inches; 2.4 ounces |
| Size | 6 Count |
| Specific Uses for Product | large |
| Style | 6 Count |
| Target Audience Keyword | ( reptiles | amphibians ), 0.2, dogs |
T**E
This stuff still works great
I bought this because I remember, this was the first thing that came out to kill fleas & ticks! I haven't seen any in years! I'm glad I found it on Amazon! Because I can't afford the other stuff & too! The other stuff I don't really trust it much! This is well worth the money, & has worked great on my 116 pound German shepherd, yup she could lose a few pounds. But she's not scratched for fleas.. she does have dry skin. There was no smell & always fell safe applying the tube opening it away from me & applying it between the shoulder's! So thankful they still make Frontline & it works! Am definitely going to be buying more!
S**H
Still works in my part of the state
Easy to apply if you can make a part in your dog's hair. I always get it on my hands and wash it off as soon as I am done with the dogs. Never a problem on my skin due to this timeliness I guess. Kills the ticks who settle down to bite and still works on fleas for me. Ten miles down the road, however, it does not work anymore. Life finds away...
M**Y
Don’t waste your time and money on this.
Didn’t work at all! Shouldn’t have wasted the time or money on this! Ended up having to go to my vet and buying a different product! From what I’ve been told frontline has been around so long fleas are resistant to it now. Wish I could get my money back on it. Just glad that after talking to my vet and getting a different product my pets are comfortable and doing well!
D**S
Many uses- goat & swine mange, chicken mites, dogs.
Fantastic for feather and leg mites in chickens, scales start falling off within days, can take a few treatments for bad infestations. Slather with neem oil also to suffocate the mites between treatments. A lot of vets recommend this off label for mange in goats, swine and camelids and it works wonderfully. Treat, then treat again in 2-4 weeks. Hair starts growing back within a few days. In 2 weeks you can hardly tell but treat again or the mites come back since the eggs are hatching- get them on a mineral buffet as well so they can balance their systems and immunity to pests. However it is not lasting the 30 days it used to for fleas in dogs. Fleas were gone for about a week after treatment. Then one or 2 started appearing again. I am going to treat dogs for fleas every 2 weeks.This is the reason for 4 stars. I buy this plus size to treat 4 small 25lb dogs. It works great for chicken leg mites and feather mites, youtube videos show you how to apply, a drop on each leg, around vent, back of neck etc. Fantastic for mange in goats and llamas- use the same weight used for a dog.
K**J
Best flea and tick med!
Arrived quickly. Always works so well for fleas and ticks for our 2 German Shepherds (very thick hair). We live on lots of land with woods so they come into contact with fleas/ticks, but when Frontline is used, we don’t have any problems. Love the bigger pack that is offered and at the best price!! Fleas: No fleas on our dogs! Ease of application: Just takes a few seconds to apply!
A**Y
Good product
Product works well, I live in Florida, off grid, in the woods. We have lots of sand, and my lab is active and always playing in the forest. I never have problems with ticks or fleas. Nats are still a pain, but I use Avons, Skin So Soft, I spray it on my hands, lightly pass over her eyes, back and tail. I've never seen skin or eye irritation from any of my dogs. From the flea control or the Skin so soft. Hope this helps.
A**R
Wouldn’t recommend ,
I don’t know if they change the formula or what happened but for some reason it does not work anymore. We were using this every month to treat our dogs and they still had fleas. Do not recommend this at least not for tough environments like Florida.
B**D
Worked better than other flea and tick treatments
Worked better than other flea and tick treatments. Lasted longer
Z**E
It says there is 6 doses inside but i received only 3 and package was opened!
Trustpilot
2 months ago
5 days ago