---
product_id: 44106689
title: "Dr. Sheffield's Anti-Itch Cream with Histamine Blocker - 1.25 Oz. (4)"
brand: "dr. sheffield's"
price: "¥3811"
currency: JPY
in_stock: true
reviews_count: 8
category: "Dr. Sheffield's"
url: https://www.desertcart.jp/products/44106689-dr-sheffields-anti-itch-cream-with-histamine-blocker-1-25
store_origin: JP
region: Japan
---

# 2% Diphenhydramine HCl for fast itch relief 0.1% Zinc Acetate skin protectant Proudly made in the USA Dr. Sheffield's Anti-Itch Cream with Histamine Blocker - 1.25 Oz. (4)

**Brand:** dr. sheffield's
**Price:** ¥3811
**Availability:** ✅ In Stock

## Summary

> 🔥 Stop the itch, start the relief — your skin’s new best friend! 🛡️

## Quick Answers

- **What is this?** Dr. Sheffield's Anti-Itch Cream with Histamine Blocker - 1.25 Oz. (4) by dr. sheffield's
- **How much does it cost?** ¥3811 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.jp](https://www.desertcart.jp/products/44106689-dr-sheffields-anti-itch-cream-with-histamine-blocker-1-25)

## Best For

- dr. sheffield's enthusiasts

## Why This Product

- Trusted dr. sheffield's brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Trusted & Proven:** Highly rated with 4.6 stars from over 1,100 users who swear by its effectiveness
- • **Soothes & Protects:** Zinc acetate forms a protective barrier to calm irritated skin
- • **Gentle & Fragrance-Free:** Ideal for sensitive, eczema-prone skin without harsh additives
- • **Dries Oozing Irritations:** Effectively dries poison ivy, oak, and sumac weeping for faster healing
- • **Rapid Itch & Pain Relief:** Targets bites, burns, sunburns, and rashes with powerful diphenhydramine action

## Overview

Dr. Sheffield's Anti-Itch Cream combines 2% diphenhydramine HCl and 0.1% zinc acetate to deliver fast, effective relief from itching and pain caused by insect bites, minor burns, sunburn, and skin irritations. This extra strength, fragrance-free formula also dries oozing poison ivy, oak, and sumac rashes, making it a must-have for anyone seeking soothing, protective care. Made in the USA and highly rated by thousands, it’s the go-to solution for managing itchy, inflamed skin with confidence.

## Description

Extra Strength Anti-Itch Cream is use for the temporarily relief from pain and itching. Dries the oozing and weeping of poison: ivy, oak, and sumac.

Review: Works well - Great product!
Review: Super effective for environmental reactions in eczema-prone skin - Like many people, I suffer from mostly mild forms of what my physician calls "chronic dermatitis." For me, it's around the hands and oddly, the outer ear canals. The condition also resembles eczema in its itchy, flaky redness and tends to be aggravated by certain environmental factors like heat, sweat and so on. In my ears, I have often woke up to an irresistible urge to scratch, swab, anything to get rid of the damned itch! After trying countless remedies, I found this stuff - simply a skin protectant with an antihistamine - the two and only tools I needed to get my condition under control. One application each and every morning and I can tell you I'm feeling at least 80% better throughout the day. A second application ups that relief even more. Since using this cream (very sparingly at that), I have felt consistent relief and a steep reduction in inflammation. This stuff is mild, fragrance-free and at this price, an absolute no-brainer for anyone seeking relief from dry, itchy patches of skin.

## Features

- INCLUDES: 1.25 ounce per tube of Dr. Sheffield's Extra Strength Anti-Itch Cream
- CONTAINS: Diphenhydramine HCl 2%, topical analgesic; Zinc acetate 0.1%, skin protectant
- FAST-RELIEF: From pain and itching associated with bites, minor burns, sunburn, minor skin irritations, and rashes
- DRIES: Oozing and weeping of poison ivy, oak, and sumac
- Made in the USA

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN  | B01N6JUSL2 |
| Best Sellers Rank | #33,464 in Grocery & Gourmet Food ( See Top 100 in Grocery & Gourmet Food ) #1,589 in Dairy, Eggs & Plant-Based Alternatives |
| Customer Reviews | 4.6 4.6 out of 5 stars (1,114) |
| Date First Available  | December 23, 2016 |
| Is Discontinued By Manufacturer  | No |
| Manufacturer  | Dr. Sheffield |
| Product Dimensions  | 8.46 x 5.83 x 1.34 inches; 7.36 ounces |

## Product Details

- **Brand:** Dr. Sheffield's
- **Item Weight:** 7.36 ounces
- **Item dimensions L x W x H:** 8.46 x 5.83 x 1.34 inches
- **Product Benefits:** Itch Control
- **Specific Uses For Product:** Insect Bites Relief

## Images

![Dr. Sheffield's Anti-Itch Cream with Histamine Blocker - 1.25 Oz. (4) - Image 1](https://m.media-amazon.com/images/I/81EF5Ftj+mL.jpg)
![Dr. Sheffield's Anti-Itch Cream with Histamine Blocker - 1.25 Oz. (4) - Image 2](https://m.media-amazon.com/images/I/81MLEj4WUjL.jpg)
![Dr. Sheffield's Anti-Itch Cream with Histamine Blocker - 1.25 Oz. (4) - Image 3](https://m.media-amazon.com/images/I/91KMYa2rAsL.jpg)

## Customer Reviews

### ⭐⭐⭐⭐⭐ Works well
*by D***Y on November 12, 2025*

Great product!

### ⭐⭐⭐⭐⭐ Super effective for environmental reactions in eczema-prone skin
*by S***R on May 5, 2022*

Like many people, I suffer from mostly mild forms of what my physician calls "chronic dermatitis." For me, it's around the hands and oddly, the outer ear canals. The condition also resembles eczema in its itchy, flaky redness and tends to be aggravated by certain environmental factors like heat, sweat and so on. In my ears, I have often woke up to an irresistible urge to scratch, swab, anything to get rid of the damned itch! After trying countless remedies, I found this stuff - simply a skin protectant with an antihistamine - the two and only tools I needed to get my condition under control. One application each and every morning and I can tell you I'm feeling at least 80% better throughout the day. A second application ups that relief even more. Since using this cream (very sparingly at that), I have felt consistent relief and a steep reduction in inflammation. This stuff is mild, fragrance-free and at this price, an absolute no-brainer for anyone seeking relief from dry, itchy patches of skin.

### ⭐⭐⭐⭐ Dr. Sheffield anti itch cream
*by D***S on December 26, 2025*

This is a great creme. It was delivered in a few days. Very pleased.

## Frequently Bought Together

- Dr. Sheffield's Anti-Itch Cream with Histamine Blocker - 1.25 Oz. (4)
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*Product available on Desertcart Japan*
*Store origin: JP*
*Last updated: 2026-01-23*