When adding new fish or changing water do I have to use the entire 5ml/10gallon rule ?

I would do it if it were me. Most fish come from pet stores that are severly overstocked and under maintained so they are already stressed when you bring them home. Add to that the fact that they are being moved for the umpteeth time and they can use all the help they can get. I will say that I do use half doses when I move my fish from one tank to another only because they tanks are well maintained and the water parameters are pretty much the same so the fish are less stressed. Other people may have different opinions but this is my process and it works for me. I have four tanks. I have a 125, 90, 55 and a 40. I have been in the hobby for over 15 years. I also keep two aquatic turtles as well. Hope this helps.

any views on this product versus API's stresscoat?

Different products, API is a water conditioner, stressguard is an antiseptic for open wounds, cuts. I used StressGuard occasionally and API on water changes.

Do you have to remove purigen from your filter

No. Generally Seachem products are safe to use with other Seachem products. Normal filters, nor purigen filters have to be removed when using Stress Guard. It's perfectly safe.

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StressGuard 500 mL / 17 fl. oz.

Product ID: 3983083

Details

Brand
Seachem
Item Form
Liquid
Item Weight
1.2 pounds
Liquid Volume
500 ml
Unit Count
16.9 Fluid

⚡reduces ammonia toxicity fast

🐟slime coat protection & healing

🧪pH neutral (7.0) formula

¥9189

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Description

🐠 Protect your aquatic friends like a pro — stress-free, safe, and scientifically proven!

POWERFUL AMMONIA DEFENSE - Effectively lowers ammonia toxicity during transport and handling.
SAFE FOR SENSITIVE TANKS - pH neutral at 7.0, perfect for reef, planted, and invertebrate aquariums.
STRESS LESS HEAL FASTER - Premium slime coat formula reduces fish stress and accelerates wound healing.
TARGETED WOUND TREATMENT - Colloidal agents bind to exposed proteins, delivering disinfectants directly to injuries.
TRUSTED BY HOBBYISTS FOR 30 YEARS - Backed by science and crafted by passionate aquarium experts.

Seachem StressGuard is a 500 mL premium aquarium conditioner designed to reduce fish stress and ammonia toxicity while promoting rapid healing of wounds. Its pH-neutral formula ensures safe use in sensitive reef and planted tanks. Trusted by hobbyists for over 30 years, StressGuard uses advanced colloidal agents to target injuries and deliver disinfectants, making it an essential treatment for transporting and handling fish.

Specifications

Asin	B001F0KX06
Best Sellers Rank	#23 in Aquarium Water Treatments
Date First Available	June 15, 2004
Department	Unisex-Adult
Item Model Number	523
Manufacturer	Seachem Laboratories, Inc.
Product Dimensions	6.6 x 2.4 x 2.3 inches; 1.15 pounds

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¥9189

Duties & taxes included

In stock

Sold byAmazon JapanDelivered byDesertcartCustomer service byDesertcartReturns14 days · 30 with PRO

Buyer Protection · Full refund if your order doesn't arrive as described.

Desertcart purchases this item on your behalf and handles shipping, customs, and support to Japan.

Secure transaction

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