---
product_id: 37274590
title: "Differin Adapalene Prescription Strength Retinoid Gel 0.1% Acne Treatment (Up to 90 Day Supply), 45 Gram"
brand: "differin"
price: "¥7857"
currency: JPY
in_stock: true
category: "Differin"
url: https://www.desertcart.jp/products/37274590-differin-adapalene-prescription-strength-retinoid-gel-0-1-acne-treatment
store_origin: JP
region: Japan
---

# Up to 90-day acne treatment supply Water-based, oil & fragrance free 0.1% Adapalene retinoid strength Differin Adapalene Prescription Strength Retinoid Gel 0.1% Acne Treatment (Up to 90 Day Supply), 45 Gram

**Brand:** differin
**Price:** ¥7857
**Availability:** ✅ In Stock

## Summary

> ✨ Clear skin, confident you. Own your glow! ✨

## Quick Answers

- **What is this?** Differin Adapalene Prescription Strength Retinoid Gel 0.1% Acne Treatment (Up to 90 Day Supply), 45 Gram by differin
- **How much does it cost?** ¥7857 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.jp](https://www.desertcart.jp/products/37274590-differin-adapalene-prescription-strength-retinoid-gel-0-1-acne-treatment)

## Best For

- differin enthusiasts

## Why This Product

- Trusted differin brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Deep Pore Power:** Targets acne at the root by normalizing skin cell turnover and unclogging pores.
- • **Gentle Yet Effective:** Formulated with adapalene for superior tolerability—perfect for daily morning or evening use.
- • **Clean & Clear Formula:** Water-based, oil-free, alcohol-free, and fragrance-free to keep skin calm and non-comedogenic.
- • **Clinically Proven Results:** Up to 87% reduction in acne lesions after 12 weeks—visible transformation you can trust.
- • **Prevents Scarring & Hyperpigmentation:** Not just clears acne but helps restore your skin’s natural tone and texture.

## Overview

Differin Adapalene 0.1% Gel is the first OTC prescription-strength retinoid acne treatment in over 30 years, clinically proven to reduce acne lesions by up to 87% in 12 weeks. Its water-based, fragrance-free formula targets clogged pores and inflammation while preventing scarring and hyperpigmentation, making it a dermatologist-recommended essential for clear, healthy skin.

## Description

Differin Gel is the First New acne active ingredient available over the counter in over 30 years and is the First and strength retinoid acne treatment Now Available without a prescription. Differin Gel contains adapalene, a multi-benefit dermatologist recommended retinoid that clears and prevents acne, which helps restore skin’s natural tone and texture.

## Features

- Clears breakouts where they start (Deep in pores) and prevents new acne from forming, which ultimately restores skin's texture and tone
- Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
- Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
- Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating Acne
- In a clinical study, Differin gel provided up to 87 percent reduction in acne lesions after 12 weeks, which will continue to improve with further use

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B01M114813 |
| ASIN  | B01M114813 |
| Best Sellers Rank | #89,897 in Beauty & Personal Care ( See Top 100 in Beauty & Personal Care ) #210 in Facial Cleansing Gels #3,317 in Facial Treatments & Masks |
| Brand Name | Differin |
| Customer Reviews | 4.6 4.6 out of 5 stars (4,021) |
| Item Form | Gel |
| Item Weight | 1.6 ounces |
| Manufacturer | Galderma Laboratories, Inc |
| Manufacturer  | Galderma Laboratories, Inc |
| Manufacturer Part Number | 302994910458 |
| Material Features | Fragrance Free |
| Package Size Name | 90 Day Supply |
| Product Benefits | Acne Preventing |
| Product Dimensions  | 3.19 x 3.94 x 7.44 inches; 1.6 ounces |
| Scent Name | Unscented |
| Size | 1.58 Ounce (Pack of 1) |
| Skin Type | All |
| Special Ingredients | Adapalene |
| Target Use Body Part | Face |
| UPC | 302994910458 |
| UPC  | 302994910458 |
| Unit Count | 1.6 Ounce |

## Product Details

- **Brand:** Differin
- **Item Form:** Gel
- **Product Benefits:** Acne Preventing
- **Scent:** Unscented
- **Skin Type:** All

## Images

![Differin Adapalene Prescription Strength Retinoid Gel 0.1% Acne Treatment (Up to 90 Day Supply), 45 Gram - Image 1](https://m.media-amazon.com/images/I/61K4fy14tSL.jpg)
![Differin Adapalene Prescription Strength Retinoid Gel 0.1% Acne Treatment (Up to 90 Day Supply), 45 Gram - Image 2](https://m.media-amazon.com/images/I/518eKkN9saL.jpg)
![Differin Adapalene Prescription Strength Retinoid Gel 0.1% Acne Treatment (Up to 90 Day Supply), 45 Gram - Image 3](https://m.media-amazon.com/images/I/61bhUFfbZ3L.jpg)
![Differin Adapalene Prescription Strength Retinoid Gel 0.1% Acne Treatment (Up to 90 Day Supply), 45 Gram - Image 4](https://m.media-amazon.com/images/I/61wTuRqoyhL.jpg)
![Differin Adapalene Prescription Strength Retinoid Gel 0.1% Acne Treatment (Up to 90 Day Supply), 45 Gram - Image 5](https://m.media-amazon.com/images/I/81GhH+jLhVL.jpg)

## Questions & Answers

**Q: Is this good for aging skin with NO acne problem?**
A: It's main indication is for acne. However, there are scholarly articles in dermatology journals, which I have open access to as a student, related to the effect of adapalene on aging skin with good results. There is also a dermatologist on YouTube using this as her first retinoid on herself and explains the difference between this and a retinol, while this could be considered not quite as credible because of it being on YouTube. There is information if you seek it out, though not as much as tretinoin on this particular topic. I have no aversion to spending money on my skin if the product works, and I would still try this over a $100 retinol product at Sephora.

**Q: Can this be used for aging skin?**
A: According to a dermatologist-Differin is a fantastic anti-aging product as it stimulates collagen production by cells in our dermis (the deeper layer of the skin),”  "This is what helps with fine lines and overall skin thickness." ... It's also the same ingredient that helps improve skin discoloration, texture and tone. It can take anywhere from 3-12 months to see improvement, but I can tell you it helped me immensely. Lightened my dark brown spots and smoothed my fine lines. It took about 3 months of every day usage to see results

**Q: Is this the same differin that I was prescribed by my dermatologist years ago?**
A: Hi Jenn, thanks for asking! Yes- Differin® Gel is the same powerful, acne-fighting formula, now even more accessible and at an affordable price. It is the first FDA approved, over the counter product to contain adapalene, the prescription strength retinoid in Differin Gel.  We hope you decide to try the product, and please feel free to reach out to our team if you have additional questions: gss@galdermaservices.com or 1-866-735- 4137 (M-F, 8a-5p CT).

**Q: How much do you use every night? Dime size, quarter size, line across your finger?**
A: Hi there! For best results, we recommend washing your face with a gentle, non-drying cleanser, such as Differin® Balancing Cleanser, applying a thin layer of Differin Gel to clean, dry skin (full face). No more than a pea-sized amount of gel should be applied in a thin layer to the face once daily. Follow the treatment with a moisturizer and SPF. We hope this is helpful!

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*Product available on Desertcart Japan*
*Store origin: JP*
*Last updated: 2026-08-03*