---
product_id: 284788688
title: "Advantage Spot On Flea Treatment For Extra Large Dogs 25 - 40kg (4 pipettes, 400mg), Kills Fleas Within 24 Hours, Prevents Further Infestation For Up To Four Weeks"
brand: "advantage"
price: "¥6812"
currency: JPY
in_stock: true
reviews_count: 9
category: "Advantage"
url: https://www.desertcart.jp/products/284788688-advantage-spot-on-flea-treatment-for-extra-large-dogs-25
store_origin: JP
region: Japan
---

# Quick skin absorption Kills fleas in 24h Protects up to 4 weeks Advantage Spot On Flea Treatment For Extra Large Dogs 25 - 40kg (4 pipettes, 400mg), Kills Fleas Within 24 Hours, Prevents Further Infestation For Up To Four Weeks

**Brand:** advantage
**Price:** ¥6812
**Availability:** ✅ In Stock

## Summary

> 🦴 Stay ahead of fleas—because your big dog deserves big protection!

## Quick Answers

- **What is this?** Advantage Spot On Flea Treatment For Extra Large Dogs 25 - 40kg (4 pipettes, 400mg), Kills Fleas Within 24 Hours, Prevents Further Infestation For Up To Four Weeks by advantage
- **How much does it cost?** ¥6812 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.jp](https://www.desertcart.jp/products/284788688-advantage-spot-on-flea-treatment-for-extra-large-dogs-25)

## Best For

- advantage enthusiasts

## Why This Product

- Trusted advantage brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Skin-Safe Formula:** Works through skin contact, no bloodstream absorption needed—safer for your pet.
- • **Long-Lasting Defense:** One application shields your pet and home for a full month.
- • **Home & Pet Protection:** Stops fleas before they bite, breaking the infestation cycle in your environment.
- • **Effortless Application:** Easy pipette design for quick, mess-free spot-on treatment.
- • **Rapid Flea Elimination:** Kills fleas within 24 hours so your dog bounces back fast.

## Overview

Advantage Spot On Flea Treatment for Extra Large Dogs (25-40kg) delivers fast-acting, clinically proven flea control by killing fleas within 24 hours and preventing reinfestation for up to four weeks. Its easy-to-apply pipette formula spreads quickly across the skin without bloodstream absorption, ensuring safe and effective protection for your pet and home.

## Description

Product Description "Help protect your pet and your home from fleas with Advantage 400 mg Spot On Solution For Extra Large Dogs between 25 - 40 kg. Our spot on flea treatment kills fleas and prevents further infestations for up to 4 weeks, as well treating biting lice in dogs. Advantage is a quick and easy-to use pipette formulation. Once applied, the product spreads quickly across your pet’s skin and coat. The product is not absorbed into the bloodstream, meaning that fleas do not have to bite to be killed 1. Advantage also kills flea larvae in the home wherever the treated pet goes. It will kill fleas within 24 hours, and is available without a prescription. Advantage can be reapplied to your dog every 4 weeks to keep them protected against fleas. Advantage Spot On is quick and easy to use: Apply one pipette of Advantage Spot On to the skin between the shoulder blades. With Advantage fleas are dead, not fed. 1. Mehlhorn H Parasitology Research 2001 198 (v1.0) 87:198-207, information is regarding mode of action and is not intended to imply parasites can be completely stopped from biting. Use medicines responsibly. Advantage contains imidacloprid. Legal category: NFA-VPS. Further information is available from the datasheet or on request. Advantage, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates. Elanco UK AH Ltd, Form 2, Bartley Wood Business Park, Bartley Way, Hook, RG27 9XA. Copyright 2025 Elanco UK AH Ltd. Date of Preparation: May 2025. PM-UK-25-0253." Directions Apply one pipette directly onto the skin at the back of the dog's neck, between the shoulder blades, and repeat every 4 weeks.

Review: Excellent and at a bargain price - Works well, no after effects, effective, my dog feels very comfortable when we put it on her. Great value for money and you get 4 in the pack, so 4 months worth. Good product that doesn't cost the earth, great at flea elimination, easy to use, instructions are simple, quick easy use.
Review: Definitely very effective! - This stuff always does the trick. For people saying it doesn't work I'd have to question whether they're applying it correctly or whether they're de-fleaing their house at the same time. It's very important that you apply this product on the skin as much as possible and try to avoid getting it on their fur to the best of your ability as it's mostly ineffective on their fur. I like these applicators as they don't scratch my cats skin. Some brands without the flat foil backed applicators that you snap to open, often leave sharp edges and I've caught my wriggly cats a couple of times with the sharp plastic. Not these ones though. They are great! Nice and safe. It's also really important that you're doing these regularly every four weeks for them to be fully effective. This was a pack of four and great value compared to some other brands. I've used these for years and been very happy with no issues.

## Features

- ADVANTAGE FLEA TREATMENT: Use Spot On Flea Treatment to keep your pets protected from fleas. Advantage spreads quickly across your pet’s skin and coat and is not absorbed into the bloodstream, meaning those pesky parasites do not have to bite to die 1.
- FAST-ACTING FLEA PROTECTION: If you suspect your pet might be suffering with fleas, take action. Advantage kills fleas within 24 hours of application, meaning your pet can get back to living a full and happy life.
- PREVENT REINFESTATION: For every adult flea that you see, there are many more eggs, larvae and pupae hidden away in carpets, upholstery and bedding. Apply spot on treatment every four weeks to prevent further infestations.
- FAST & SIMPLE TO APPLY: Protect your pets from fleas with our easy to apply pipette formulation. Apply one pipette evenly to three to four spots on the top of the back from the shoulder to the base of the tail.
- PROTECT YOUR PET, PROTECT YOUR HOME: If your pet has fleas, your home has fleas. Advantage is clinically proven to kill fleas, giving you peace of mind. With Advantage Flea Treatment, fleas are dead, not fed.

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B00OHPZM98 |
| Best Sellers Rank | 28 in Pet Supplies ( See Top 100 in Pet Supplies ) 1 in Dog Flea Drops |
| Breed Recommendation | Large Breeds |
| Customer Reviews | 4.6 4.6 out of 5 stars (16,675) |
| Date First Available | 14 Oct. 2014 |
| Item Form | Drops |
| Manufacturer reference | H070658 |
| Number of Items | 4 |
| Pet Life Stage | All Life Stages |
| Pet Type | Dog |
| Quantity | 1 |
| Size | Extra Large Dogs (25-40 kg) |

## Product Details

- **Active ingredients:** Imidacloprid
- **Age range (description):** All Life Stages
- **Brand:** Advantage
- **Dog Breed Size:** Large
- **Item form:** Drops

## Images

![Advantage Spot On Flea Treatment For Extra Large Dogs 25 - 40kg (4 pipettes, 400mg), Kills Fleas Within 24 Hours, Prevents Further Infestation For Up To Four Weeks - Image 1](https://m.media-amazon.com/images/I/81gFNeUND0L.jpg)

## Available Options

This product comes in different **Size** options.

## Questions & Answers

**Q: is this item easy to use**
A: Yes very easy to use ,my cat had been used to other spot on  with little effect .After using Advantage for the first but definitely not the last time after other's online recommendations ,I watched the fleas literally falling off my cat whilst they were dying almost immediately ,I would say very  effective

**Q: I  have a Chihuahua and we live in Egypt six months of the year. Comments about efficacy of this product(Advantage), with ticks would be very welcome**
A: Hiya. Live in Cheshire here. We have all sorts of creepy critters that love to attach themselves to my dogs and cats, free meal all round! I researched this product after wasting so much money on frontline, this didn't work for me anymore. I purchased just before Xmas and dropped it on animals, within minutes I spotted a flea trying to hang onto my dog's coat (probably gasping for air, didn't get magnifying glass out!) ;) there have been no fleas, ticks or mites on any of my 7 animals since! :) will be buying again next month to repeat. It's brilliant and really works.

**Q: Is it the same ingredients for cats & dogs ?**
A: Advantage Spot On Flea Treatment is for treating flea infestations in dogs, cats and rabbits suitable for puppies and kittens 8 weeks and older. Using Advantage Flea Treatment, fleas are killed within one day following treatment.

**Q: does this product kill ticks?**
A: No it doesn't. I started using this 2 weeks ago. I found a tick on my dog 5 days ago. I recieved my 'tick remover' today and have just removed the tick and it was still alive! I've just drowned the horrid tick in mouthwash, vinegar and bleach! So I would say NO this product does not kill ticks.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Excellent and at a bargain price
*by F***3 on 4 January 2026*

Works well, no after effects, effective, my dog feels very comfortable when we put it on her. Great value for money and you get 4 in the pack, so 4 months worth. Good product that doesn't cost the earth, great at flea elimination, easy to use, instructions are simple, quick easy use.

### ⭐⭐⭐⭐⭐ Definitely very effective!
*by L***P on 1 February 2026*

This stuff always does the trick. For people saying it doesn't work I'd have to question whether they're applying it correctly or whether they're de-fleaing their house at the same time. It's very important that you apply this product on the skin as much as possible and try to avoid getting it on their fur to the best of your ability as it's mostly ineffective on their fur. I like these applicators as they don't scratch my cats skin. Some brands without the flat foil backed applicators that you snap to open, often leave sharp edges and I've caught my wriggly cats a couple of times with the sharp plastic. Not these ones though. They are great! Nice and safe. It's also really important that you're doing these regularly every four weeks for them to be fully effective. This was a pack of four and great value compared to some other brands. I've used these for years and been very happy with no issues.

### ⭐⭐⭐⭐ It works
*by E***N on 1 August 2025*

It's pretty good, unfortunately the flees are not complete gone but my dogs haven't reacted , seem more relaxed. Will be using again as I can see it's working along side flee baths. Dogs resistany as no ticks found and have used for a 4 months

## Frequently Bought Together

- Advantage Spot On Flea Treatment 400 Extra Large Dogs 25-40kg, 4 pipettes
- Bob Martin Clear 3-in-1 Wormer for Dogs (4 Tablets) - For Small, Medium and Large Dogs up to 40kg, Clinically Proven Treatment

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*Product available on Desertcart Japan*
*Store origin: JP*
*Last updated: 2026-02-23*