--- product_id: 247862108 title: "Nitric Oxide Activating Anti-Aging Face Serum, 20% Vitamin C, 1 Fl Oz | Developed by Dr. Nathan S Bryan, Hydrating Serum, Minimizes Dark Spots, Promotes Smoother-Looking Skin, Reduces Fine Lines" brand: "n1o1" price: "¥38341" currency: JPY in_stock: true reviews_count: 8 url: https://www.desertcart.jp/products/247862108-nitric-oxide-activating-anti-aging-face-serum-20-vitamin-c store_origin: JP region: Japan --- # 20% Stable Vitamin C antioxidant Hydrating Nitric Oxide boost Dual-chamber nitric oxide delivery Nitric Oxide Activating Anti-Aging Face Serum, 20% Vitamin C, 1 Fl Oz | Developed by Dr. Nathan S Bryan, Hydrating Serum, Minimizes Dark Spots, Promotes Smoother-Looking Skin, Reduces Fine Lines **Brand:** n1o1 **Price:** ¥38341 **Availability:** ✅ In Stock ## Summary > ✨ Unlock your skin’s youthful glow with science-backed brilliance! 🍊💧 ## Quick Answers - **What is this?** Nitric Oxide Activating Anti-Aging Face Serum, 20% Vitamin C, 1 Fl Oz | Developed by Dr. Nathan S Bryan, Hydrating Serum, Minimizes Dark Spots, Promotes Smoother-Looking Skin, Reduces Fine Lines by n1o1 - **How much does it cost?** ¥38341 with free shipping - **Is it available?** Yes, in stock and ready to ship - **Where can I buy it?** [www.desertcart.jp](https://www.desertcart.jp/products/247862108-nitric-oxide-activating-anti-aging-face-serum-20-vitamin-c) ## Best For - n1o1 enthusiasts ## Why This Product - Trusted n1o1 brand quality - Free international shipping included - Worldwide delivery with tracking - 15-day hassle-free returns ## Key Features - • **Universal Skin Compatibility:** Gentle yet effective for all skin types, from sensitive to oily. - • **Deep Hydration & Moisture Lock:** Supports supple, smooth skin texture without harsh chemicals. - • **Powerful 20% Vitamin C Complex:** Delivers potent antioxidant protection for brighter, even-toned skin. - • **Nobel Prize-Winning Nitric Oxide:** Activates skin’s natural youth molecule to visibly reduce wrinkles and dark spots. - • **Clinically Proven Anti-Aging Formula:** Backed by 4 clinical studies and 20 years of research for trusted results. ## Overview N1O1 Nitric Oxide Activating Anti-Aging Face Serum combines a Nobel Prize-winning nitric oxide technology with a potent 20% Vitamin C formula to combat the root causes of skin aging. Clinically proven to reduce fine lines, dark spots, and uneven tone, this hydrating serum supports collagen production and nutrient flow for visibly smoother, brighter skin. Suitable for all skin types, it offers a clean, chemical-free approach to daily anti-aging skincare. ## Description N1O1 is the first anti-aging skin care serum that uses the Nobel Prize-winning discovery of Nitric Oxide in combination with 20% vitamin c to defy aging skin by correcting the cause of aging and help reduce the appearance of wrinkles, dark spots and fine lines. N1o1 stimulates collagen production and may support the youthful flow of oxygen, hydration, and nutrients to your skin cells. The problem is our body makes less Nitric Oxide as we get older. This is the reason your skin ages. Loss of Nitric Oxide = Accelerating Aging. N1o1 helps restore the missing Nitric Oxide to get to the root cause of aging skin. The result: wrinkles and dark spots disappear, tone improves and you’ll love the way your skin looks and feels. The results are backed by 20 years of research and science and proven effective in 4 Clinical Studies. Nitric Oxide is a molecule produced by the human body. As we age, Nitric Oxide production diminishes by as much as 50% by age 40. Science has proven that the loss of Nitric Oxide production accelerates the aging process from cardiovascular function to the signs of aging of the skin. N1o1's unique patent-pending formula contains powerful antioxidant ingredients including 20% Vitamin C and it’s dual-chamber delivery system generates nitric oxide molecules you can actually see working on the skin within seconds. By activating nitric oxide production at the surface of the skin and within the dermis, the skin is in an optimally receptive state. Nitric Oxide is so important to human health and aging that its discovery led to a Nobel Prize in Physiology & Medicine 1998. Apply 1x daily proactively in your 20's, 1 - 2 x daily for aging and damaged skin in your 40's; Dermatologists and Skin Care professionals recommend 2x daily for damaged and aging skin. Use N1O1 for wrinkles, pore size, skin town, skin texture, clarity, dark spots and more. ## Features - Hydrating And Moisturizing: Our moisturizing face serum combines Nitric Oxide with Vitamin C to bring you a facial serum that will help support smooth, supple and soft skin without relying on any harsh chemicals or additives for day to day skincare - Brighter And Smoother Skin: Our facial skin care serum with Nitric Oxide helps support collagen, hydration, and nutrient flow to your skin to help reduce the visibility of fine lines, dark spots, and other signs of aging without relying on any harsh chemicals or additives - Even Skin Tone Support: This skin brightening serum contains 20% stable Vitamin C that not only helps moisturize the skin but also helps provide antioxidant support to help reduce oxidative stress by helping neutralize free-radicals to support an even and brighter skin tone - Suitable For All Skin Types: The vitamin C face serum utilizes Nitric Oxide along with a balanced formula to help support the skin without relying on any harsh chemicals. This nitric oxide and Vitamin C serum is suitable for dry, oily, normal, and sensitive skin to offer gentle support - Simple To Use: Each bottle of activating serum can provide up to a 30 day supply. Simply apply a single pump of serum to your palm, gently massage it onto your face and neck, and let it rest for 1-2 minutes. Our vitamin C serum can be applied both during the day and night ## Technical Specifications | Specification | Value | |---------------|-------| | Asin | B08LNTJZST | | Best Sellers Rank | #1,200 in Facial Serums | | Item Model Number | n1o1 | | Manufacturer | Pneuma Nitric Oxide | | Product Dimensions | 6 x 2 x 2 inches; 3.53 ounces | | Upc | 608597658903 | ## Product Details - **Product Benefits:** Anti-Aging - **Scent:** Fragrance Free - **Skin Type:** All - **Special Ingredients:** Antioxidants, Vitamin C, Vitamin E - **Use for:** Face ## Images ![Nitric Oxide Activating Anti-Aging Face Serum, 20% Vitamin C, 1 Fl Oz | Developed by Dr. Nathan S Bryan, Hydrating Serum, Minimizes Dark Spots, Promotes Smoother-Looking Skin, Reduces Fine Lines - Image 1](https://m.media-amazon.com/images/I/519vaxPub-L.jpg) ## Questions & Answers **Q: What color is the serum supposed to be directly out of the bottle?** A: The bottle is a dual chamber system - one side of the bottle contains vitamin C, the other side contains liquid nitric oxide. When you use one pump from each side of the bottle, and mix the drops together in the palm of your hand, the vitamin C acts as the activating ingredient to activate the nitric oxide. The nitric oxide serum is clear, the vitamin C can be an amber color. **Q: Should I use hyaluronic acid in addition to this, or does this replace hyaluronic acid?** A: Thank you for reaching out! You should use Hyaluronic Acid after using our Nitric Oxide Activating Serum. The serum help with the absorption of the HA...and will actually boost it! Hope this helps! **Q: What percentage of nitric oxide?** A: Thank you for asking! The serum is a dual chamber bottle that contains nitrite in one chamber and Vitamin C in the other. The vitamin C is the activating agent which when mixed with the nitrite creates nitric oxide gas. The mixture is 100% nitric oxide. Hope this helps. **Q: is it animal tested?** A: No, our products are never animal tested. ## Customer Reviews ### ⭐⭐⭐⭐⭐ Removed my scar, despite infrequent use *by on Reviewed in the United States August 26, 2025* Three years ago, I cut my face right in between my eyebrows. I got left with a 1/4” scar that ran deep, extended my wrinkle and gave me a permanently worried look.It got worse over time. My trusty moisturizer helped everywhere, except for the scar. The need to do something overcame my skepticism about nitric oxide, so I decided to give it a chance. I had no expectations.The instructions recommend daily application. I applied about twice a week. For a couple weeks, there was no change. Maybe a month later I noticed the scar is no longer joined to my eyebrow wrinkle, reducing my angry, worried look.I began applying every other day and after a few more weeks, the scar is now flat and only visible within a few feet distance. By flat I mean no longer deep, almost completely flush with the skin, with a very slightly discolored center.The scar basically shrank in size and almost disappeared optically. My wrinkles also improved substantially.I now believe that the scar will disappear completely with another few weeks of frequent use. I started to apply all over my face and neck, since the minimum dose is large enough.I’m now administering to whoever asks: seniors, youth, children, … whoever has skin damage.The cream itself clogs pores a little so I shower it off at the end of the day. It’s not suitable for wearing light colors as it can stain them yellow. I wish it came in glass instead of plastic.I thought I’d keep my scar for the rest of my life, looking progressively angrier as I age. And yet, here we are - I’ve reversed three years of skin damage.Thank you Dr. Nathan Bryer! ### ⭐⭐⭐⭐⭐ This is the one to buy!! I've tested many expensive ones!! *by on Reviewed in the United States August 9, 2026* As I started seeing changes in my skin, I searched for solutions and was influenced into buying multiple products that had no ROI, I don't expect results over night, in fact I believe if you're using a topical, it might take months and multiple bottles to start seeing changes. That said, I still get a feel for a product earlier on.I bought this after I watched a podcast with the doctor who invented it and felt he was sincere and skilled (knowing the science is a far cry from product development) I had been frustrated with a different product (more expensive with terrible packaging) I bought this and on the first application I felt it was "real", by the first week I can see better skin emerging, I'm still mid first bottle, and now want to order more products from them. Some days I see results more than others, but I know without a doubt this works!! I'm excited to see the changes over time.The one feedback I would give the brand is on packaging, the vitamin C side sort of sprays out at times, not that it wastes product but feels like I get less than the other side. so be mindful of that when you use it.**bottom line: This is effective, absorbs right away, I barely wait to moisturize after, and I think you get a good amount for the money.-Cons: Not a true con but packaging could be better but I understand they want to control dosing, I just feel viscosity is different on both sides therefore it should be a different dispenser. This will not stop me from buying again and I HIGHLY RECOMMEND THIS!! Buy this so you start seeing results, it's refreshing ### ⭐ Allergic Reaction - No Go *by on Reviewed in the United States March 11, 2026* This serum broke my face and neck out with red bumps and itchy skin. I wasn't sure if it was the product so I stayed off of it for a week and then used it one more time. Huge allergic reaction and has caused me to have itchy skin and irritated skin. I do not like this product for me. I ordered it based on a segment shown on DayStar TV. Apparently Joni uses it but I can not tolerate the product. ## Frequently Bought Together - Nitric Oxide Activating Serum with Antioxidants | Hydrating Serum For Face | Decreases Wrinkles | Pore Minimizer | Improves Skin Texture | Helps Dark Spots | 1 Fl Oz, 30ml - N1O1 Nitric Oxide Lozenges - 60 Count - Nitric Oxide Supplement for Heart Health, Circulation, Energy, Blood Flow, Oxygenation, Healthy Blood Pressure, Cardiovascular Support for Men & Women - N1O1 Moisturizer Face Cream - Day & Night Face Moisturizer with Nitric Oxide, Peptide Complex, Epidermal Growth Factor - Tightening & Firming Skin Care Products for Wrinkles, Dark Spots - 1.75 oz. --- ## Why Shop on Desertcart? - 🛒 **Trusted by 1.3+ Million Shoppers** — Serving international shoppers since 2016 - 🌍 **Shop Globally** — Access 737+ million products across 21 categories - 💰 **No Hidden Fees** — All customs, duties, and taxes included in the price - 🔄 **15-Day Free Returns** — Hassle-free returns (30 days for PRO members) - 🔒 **Secure Payments** — Trusted payment options with buyer protection - ⭐ **TrustPilot Rated 4.5/5** — Based on 8,000+ happy customer reviews **Shop now:** [https://www.desertcart.jp/products/247862108-nitric-oxide-activating-anti-aging-face-serum-20-vitamin-c](https://www.desertcart.jp/products/247862108-nitric-oxide-activating-anti-aging-face-serum-20-vitamin-c) --- *Product available on Desertcart Japan* *Store origin: JP* *Last updated: 2026-08-20*