---
product_id: 23133826
title: "Zylkene Calming Support Supplement for Medium Dogs 33-65lbs Helps Promote Relaxation and Reduce External Stress Factors, Daily Behavioral Support and Anxiety Relief for Dogs, 225mg"
brand: "vetoquinol"
price: "¥19059"
currency: JPY
in_stock: true
reviews_count: 8
category: "Vetoquinol"
url: https://www.desertcart.jp/products/23133826-zylkene-calming-support-supplement-for-medium-dogs-33-65lbs-helps
store_origin: JP
region: Japan
---

# Lactose-free & natural ingredients 33-65 lbs medium dog size 225mg Alpha-Casozepine active calming protein Zylkene Calming Support Supplement for Medium Dogs 33-65lbs Helps Promote Relaxation and Reduce External Stress Factors, Daily Behavioral Support and Anxiety Relief for Dogs, 225mg

**Brand:** vetoquinol
**Price:** ¥19059
**Availability:** ✅ In Stock

## Summary

> 🐾 Calm, Confident, Connected — Because Your Dog Deserves the Best Chill

## Quick Answers

- **What is this?** Zylkene Calming Support Supplement for Medium Dogs 33-65lbs Helps Promote Relaxation and Reduce External Stress Factors, Daily Behavioral Support and Anxiety Relief for Dogs, 225mg by vetoquinol
- **How much does it cost?** ¥19059 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.jp](https://www.desertcart.jp/products/23133826-zylkene-calming-support-supplement-for-medium-dogs-33-65lbs-helps)

## Best For

- vetoquinol enthusiasts

## Why This Product

- Trusted vetoquinol brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Trusted by Thousands:** 4.0-star rating from 1,535 reviews proves real-world success and peace of mind.
- • **Targeted Stress Relief:** Effectively reduces stress from travel, vet visits, loud noises, and separation.
- • **Natural & Gentle Formula:** Alpha-Casozepine derived from milk protein promotes calmness without drowsiness or stomach upset.
- • **Vet-Backed Calming Power:** Clinically recommended daily support to ease your dog's anxiety without sedation.
- • **Effortless Administration:** Open capsule and mix with food—simple daily routine for busy pet parents.

## Overview

Vetoquinol Zylkene is a veterinarian-recommended calming supplement designed for medium dogs (33-65 lbs). Featuring 225mg of natural Alpha-Casozepine, it supports daily behavioral health by reducing anxiety and stress from common triggers like travel and loud noises. This lactose-free, flavorless capsule is easy to administer by mixing into food, providing gentle, non-sedative relief that helps your dog stay relaxed and balanced.

## Description

desertcart.com : Vetoquinol Zylkene Calming Support Supplement for Medium Dogs 33-65lbs Helps Promote Relaxation and Reduce External Stress Factors, Daily Behavioral Support and Anxiety Relief for Dogs, 225mg : Pet Supplies

Review: Don’t hesitate! - Seriously buy this. Our pug has evening anxiety ever since the 4th of July. The vet prescribed Trazodone which made it so much worse and then she gave her Gabapentin which knocked her out and we don’t want to sedate her. The vet suggested to give this product a try and I can’t even believe how well it works, I would assume it was a script if I hadn’t known. We give it to her around 3:30 and by 5 she’s calm and chill, she is a little sleepy but more relaxed. It does not last all day. She is more like her normal self around 9:30 which is great bc it’s bedtime.
Review: Miracle in a Pill - Okay, this is going to sound like it was written by a relative, but I'm just your normal, average animal freak with five resident dogs and seven cats (two are fosters). Over the years we've had probably a hundred or more animals in our home, and we tend to adopt the misfits. Mango, our overanxious, neurotic rat terrier is one of our bigger challenges. She has to modes: catatonic and, as my friend put it, "tiny psycho dog." Over the years, we've done any number of behavioral, homeopathic, and medical interventions with only modest success. After a series of very volatile outbursts, our vet put her on a strong antianxiety medication before. We were thinking we may need to prepare ourselves for euthanasia, something we aren't in a rush to do, but after three years and thousands of dollars, we were running low on options. The drugs worked, but she was so zonked out there were nights we had to literally carry her upstairs. We knew we had to wean her off of the drugs but we were apprehensive about her reverting back to her old ways. The vet said one of the other vets had good luck with Zylkene, and said while it's spendy, maybe it was worth a shot. Since she's been completely off the drugs and exclusively on the Zylkene (about 3 months), she's gone from several occurrences of attacking the other animals (and occasionally is) a DAY to maybe twice in the past three months, and very easy to redirect to preferred behavior. I truly believe this stuff has saved the life of the dog who stole my heart. She's a confident and affectionate little girl who not only doesn't fight with her siblings, but actually cuddles with them! Remarkable! I haven't had the same luck with our other anxious dogs, but if say it's worth a shot of you're at wit's end.

## Features

- Help Your Pet Cope With External Stress - Zylkene helps your pet cope with changes in their daily routine, such as travel, celebrations, vet visits, home alone, boarding, loud noises, and more
- Alpha-Casozephine - A naturally occurring milk protein found in cow's milk that helps promote calming effects in your pet without drowsiness or other side effects found in other calming chews for dogs
- Lactose-Free and Easy on Sensitive Stomachs - Zylkene's dog calming and cat calming supplements are lactose-free and made with natural ingredients that are easy on sensitive stomachs
- Veterinarian Recommended Daily Calming Support - Zylkene promotes calming in dogs and cats and can be given daily for behavior support and to help deal with unexpected external stresses
- Easy to Administer - Open the capsule of Zylkene and add it to your pet's food daily to help them cope with external stresses like separation and improve daily behavior

## Technical Specifications

| Specification | Value |
|---------------|-------|
| Active Ingredients | Dried hydrolyzed casein, maltodextrin, magnesium stearate |
| Brand | Vetoquinol |
| Customer Reviews | 4.0 out of 5 stars 1,535 Reviews |
| Flavor | Flavorless |
| Item Form | Capsule |
| Item Volume | 1 |
| Item Weight | 0.1 Grams |

## Product Details

- **Active Ingredients:** Dried hydrolyzed casein, maltodextrin, magnesium stearate
- **Brand:** Vetoquinol
- **Flavor:** Flavorless
- **Item Form:** Capsule
- **Item Weight:** 0.1 Grams

## Images

![Zylkene Calming Support Supplement for Medium Dogs 33-65lbs Helps Promote Relaxation and Reduce External Stress Factors, Daily Behavioral Support and Anxiety Relief for Dogs, 225mg - Image 1](https://m.media-amazon.com/images/I/71CI21VlQdL.jpg)

## Available Options

This product comes in different **Size** options.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Don’t hesitate!
*by L***N on August 3, 2025*

Seriously buy this. Our pug has evening anxiety ever since the 4th of July. The vet prescribed Trazodone which made it so much worse and then she gave her Gabapentin which knocked her out and we don’t want to sedate her. The vet suggested to give this product a try and I can’t even believe how well it works, I would assume it was a script if I hadn’t known. We give it to her around 3:30 and by 5 she’s calm and chill, she is a little sleepy but more relaxed. It does not last all day. She is more like her normal self around 9:30 which is great bc it’s bedtime.

### ⭐⭐⭐⭐⭐ Miracle in a Pill
*by J***H on June 7, 2016*

Okay, this is going to sound like it was written by a relative, but I'm just your normal, average animal freak with five resident dogs and seven cats (two are fosters). Over the years we've had probably a hundred or more animals in our home, and we tend to adopt the misfits. Mango, our overanxious, neurotic rat terrier is one of our bigger challenges. She has to modes: catatonic and, as my friend put it, "tiny psycho dog." Over the years, we've done any number of behavioral, homeopathic, and medical interventions with only modest success. After a series of very volatile outbursts, our vet put her on a strong antianxiety medication before. We were thinking we may need to prepare ourselves for euthanasia, something we aren't in a rush to do, but after three years and thousands of dollars, we were running low on options. The drugs worked, but she was so zonked out there were nights we had to literally carry her upstairs. We knew we had to wean her off of the drugs but we were apprehensive about her reverting back to her old ways. The vet said one of the other vets had good luck with Zylkene, and said while it's spendy, maybe it was worth a shot. Since she's been completely off the drugs and exclusively on the Zylkene (about 3 months), she's gone from several occurrences of attacking the other animals (and occasionally is) a DAY to maybe twice in the past three months, and very easy to redirect to preferred behavior. I truly believe this stuff has saved the life of the dog who stole my heart. She's a confident and affectionate little girl who not only doesn't fight with her siblings, but actually cuddles with them! Remarkable! I haven't had the same luck with our other anxious dogs, but if say it's worth a shot of you're at wit's end.

### ⭐ Doesn’t work
*by M***R on June 28, 2025*

This had 0 effect on my dog’s anxiety. I’ve been using this for the past 3 weeks and there was no change whatsoever. It’s unfortunate how expensive this item is and it’s non-returnable.

## Frequently Bought Together

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*Product available on Desertcart Japan*
*Store origin: JP*
*Last updated: 2026-02-25*