---
product_id: 16887578
title: "Jarrow Same Supplement 400 mg, Extra Strength, 60 Tablets"
brand: "jarrow formulas"
price: "¥19142"
currency: JPY
in_stock: true
reviews_count: 11
category: "Jarrow Formulas"
url: https://www.desertcart.jp/products/16887578-jarrow-same-supplement-400-mg-extra-strength-60-tablets
store_origin: JP
region: Japan
---

# 400 mg active S,S form SAMe Supports joint & connective tissue health Boosts brain metabolism & balanced mood Jarrow Same Supplement 400 mg, Extra Strength, 60 Tablets

**Brand:** jarrow formulas
**Price:** ¥19142
**Availability:** ✅ In Stock

## Summary

> 💥 Elevate your wellness game with the power of pure SAMe!

## Quick Answers

- **What is this?** Jarrow Same Supplement 400 mg, Extra Strength, 60 Tablets by jarrow formulas
- **How much does it cost?** ¥19142 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.jp](https://www.desertcart.jp/products/16887578-jarrow-same-supplement-400-mg-extra-strength-60-tablets)

## Best For

- jarrow formulas enthusiasts

## Why This Product

- Trusted jarrow formulas brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Mood & Cognitive Boost:** Enhances neurotransmitter synthesis for balanced mood and brain metabolism
- • **Potent 400 mg Active S,S Form:** Highest bioavailable SAMe concentration for maximum efficacy
- • **Triple-Action Wellness Support:** Joint health, liver function, and antioxidant defense in one tablet
- • **Vegan, Non-GMO & Allergen-Free:** Clean, inclusive formula fits any lifestyle or dietary restriction
- • **Enteric Coated for Superior Absorption:** Low-temp manufacturing preserves potency and ensures delivery where it counts

## Overview

Jarrow Formulas SAMe 400 mg delivers a high concentration of the biologically active S,S form of SAMe, supporting joint health, liver function, antioxidant defense, and balanced brain chemistry. Its enteric coating ensures optimal absorption, while the vegan, non-GMO, and allergen-free formula fits seamlessly into any health-conscious lifestyle.

## Description

Jarrow Formulas SAM-e provides S-Adenosyl Methionine, a naturally derived compound that plays a role in supporting multiple biochemical systems in the body.(1) Each tablet supplies 400 mg of SAM-e to help maintain joint health and liver function.(1) As a joint support supplement, it fits easily into the daily routine of any health-conscious individual interested in overall wellness.(1) The vegan, non-GMO tablets do not contain gluten, wheat, soy, dairy, egg, fish/shellfish, peanut/nut or sesame, so they suit those with dietary restrictions. Whether used as a stand alone supplement at home or taken with a multivitamin, adults simply consume one easy to swallow tablet by mouth with water on an empty stomach, or as directed by a qualified healthcare professional. Jarrow Formulas continues its original mission to design superior dietary supplements that empower people in their quest for healthy living and a tailored wellness regimen. (1) These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Review: Cannot recommend enough - Mental illness runs deep in my family and I've been on antidepressant medication for decades after struggling with mood since puberty. When my lovely, happy tween daughter suddenly took to her room crying unable to express the depth of despair that seemed to grab her out of nowhere, there are no words for how helpless and overwhelmed I felt. After taking her to a highly-recommended adolescent therapist, she agreed that she was likely experiencing more than just normal adolescent blues and expressed concerns about some of the dark thoughts she was starting to have. I know medication has saved my life and I was committed to doing whatever was indicated to treat her, including antidepressant medication. However, the therapist assured me that she was keeping a close eye on my daughter and felt I had some breathing room to try some supplements before starting medication. Again, I'm NOT anti-med, but the rapid brain development at her young age and some bothersome side effects prompted me to try supplements first. I researched and decided on either 5-HTP (+actually tested and used extensively in kids for other indications, -potential liver toxicity) vs. SamE (+proven efficacy and first line treatment for depression in Europe, no know SE's at any dose, -no clinical trials in kids). I decided on SamE and researched that Jarrow was a good brand for efficacy and purity. I expected a slight and gradual improvement in her mood after a few weeks. Two days at 200 mg- not much change, 2 days at 400 mg and she's markedly improved, then up to 600 mg and I could not believe what I was seeing. She was almost the same kid as before and other than a few blips (she is still a teen), she's been that way for a few months. So much so, it has me wondering if I should work with my dr. to get off cymbalta and onto SamE. A few points to consider- I'm a nurse and pretty knowledgeable about depression due to my own struggles, so I will try not to get too deep into the science but I've always suspected a genetic mutation (will test when I have $200 to spare) that causes poor methylation. Neurotransmitters like dopamine and seratonin require methylation to be available in the right amounts and there are some new treatments being researched and even sold that target methylation pathways. Sam-e targets methylation and I'd read that it helps it work better if you take a methylated folate supplement. Omega -3's, vitamin d, and Mg also have demonstrated effects on mood. So, I am also giving her a quality supplement that contains these too. We are also fortunate enough that we can pay to send her to a good behavioral therapist. I'm sure that those things are also helpful but the SamE is def. the thing that seemed to give her the immediate and noticeable boost in mood. The only negative is that it's expensive and, needless to say, insurance won't pay. But I'll take another job selling my plasma or driving for uber if I have to, because i think it's sparing my daughter the acute suffering that I've experienced first hand and seen claim the lives of people I love. FYI- I know this is a product review, not a self help article but I know ppl with depression will be reading this looking for hope. If this is you- do WHATEVER it takes (including prescribed meds or conventional treatments) to get help!
Review: I am so amazed with this product - I have used desertcart for almost 10 years and I've never written a review because I'm just not the type to do so, nor do I have the time or energy to put in the effort. However, I am so amazed with this product, I have a burning desire to share my positive experience. First of all, I have tried EVERYTHING to help depression. Seriously. I've always experienced prescription drugs to be too much for my system no matter the dosing and the time I waiting the side effect out. With Sam-e, I started out taking 400s right as I woke up. (30 min before breakfast.) The first 5-6 days, I experienced heightened anxiety and insomnia. I remember one night just wide eyed thinking that it was ridiculous that I couldn't sleep. After about 5-6 days, I started to sleep normal again and the anxiety tapered off. Before I even realized it, I was just level. It's hard to explain. The edge was taken off. I've been really stressed out and depressed, and I'm in my second year of nursing school. Now, 2 months on Sam-e, the stress is minimal because I am able to control my perception on situations and life so much better. Control is something I've never had with my emotions or mental being. I've struggled with a little OCD, depression to where I wouldn't leave the house, sometimes not get out of bed and I would sit in my car for hours because I just felt like I couldn't move. I wouldn't even go into a grocery store because I didn't feel confident to deal with people or strangers. Sam-e has saved my life! That sounds so cliché but I am being as authentic as I can here. I don't feel like I'm on anything and I have zero side effects. I've not felt like I needed to adjust my dosing, as some people feel they need to bump up to higher doses to feel more of an affect. I did do a lot of research before taking Sam-e and I do take folic acid and a B complex. Apparently, those two supplements prevent a certain chemical from building up in your body from taking Sam-e. All in all, I am just so grateful to be one of the 5 star reviewers. I remember reading these same reviews praying that Sam-e would be a miracle for me and it is! My best advice is it doesn't hurt to try. Give it time.. If you feel the anxiety and insomnia, just hang in there. And take the folic acid and b complex with it; maybe that makes a difference. Wish you the best!

## Features

- High Concentration of Active S,S Form: the biologically active form of SAMe uses the S,S structure; the fermentation without chemical solvents preserves 68-80% of Sam-e 400mg, the highest level available
- Joint Health, Liver Function and Antioxidant Defense: SAMe 400mg supports the production of healthy connective tissue; plus, SAM e 400mg metabolism supports the synthesis of glutathione, critical for antioxidant defenses and liver functions (1)
- Brain Metabolism and Mood: SAM-e supplement's methylation reactions are involved in the synthesis of phosphatidylcholine and neurotransmitters such as dopamine, norepinephrine, and serotonin; SAMe supports a balanced mood (1)
- Enteric Coating: SAMe supplement is a metabolite of methionine, provides 400 mg from 800 mg SAMe tosylate disulfate and is manufactured under low temperature, enteric-coated to ensure a biologically active product
- Superior Nutrition and Formulation: Jarrow Formulas aims to promote optimal health with effective, affordable vitamins and supplements; customers are assured of purity and value

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B00V3M9CYY |
| Age Range Description | Adult |
| Best Sellers Rank | #26,959 in Health & Household ( See Top 100 in Health & Household ) #895 in Blended Vitamin & Mineral Supplements #1,915 in Sales & Deals |
| Brand | Jarrow Formulas |
| Brand Name | Jarrow Formulas |
| Color | 60 Count |
| Container Type | Bottle |
| Customer Reviews | 4.3 out of 5 stars 1,338 Reviews |
| Diet Type | Vegan, Vegetarian |
| Dosage Form | 400 mg |
| Flavor | Unflavored |
| Global Trade Identification Number | 00790011200420 |
| Item Dimensions | 1.75 x 3.25 x 6 inches |
| Item Form | Tablet |
| Item Highlight | High Concentration Of Active S,S Form, Supports Joint Health, Liver Function, Brain Metabolism, Mood & Antioxidant Defense |
| Item Weight | 3.36 ounces |
| Manufacturer | Jarrow Formulas |
| Manufacturer Part Number | SAM460 |
| Material Features | Gluten Free |
| Model Name | SAMe 400 |
| Model Number | SAM460 |
| Number of Items | 1 |
| Package Size Name | 60 Count |
| Primary Supplement Type | Vitamin |
| Product Benefits | Bone & Joint Support, Stress Relief |
| Recommended Uses For Product | Joint Health, Liver Function, Brain Metabolism, Mood Support, Stress Relief, Bone & Joint Support |
| Special Ingredients | Amino Acid |
| Total Servings Per Container | 60 |
| UPC | 790011200420 784922636478 |
| Unit Count | 60 Count |

## Product Details

- **Brand:** Jarrow Formulas
- **Diet Type:** Vegan, Vegetarian
- **Flavor:** Unflavored
- **Item Form:** Tablet
- **Item Weight:** 3.36 ounces
- **Item dimensions L x W x H:** 1.75 x 3.25 x 6 inches
- **Primary Supplement Type:** Vitamin
- **Product Benefits:** Bone & Joint Support, Stress Relief
- **Special Ingredients:** Amino Acid
- **Unit Count:** 60 Count

## Images

![Jarrow Same Supplement 400 mg, Extra Strength, 60 Tablets - Image 1](https://m.media-amazon.com/images/I/71VugxXba7L.jpg)
![Jarrow Same Supplement 400 mg, Extra Strength, 60 Tablets - Image 2](https://m.media-amazon.com/images/I/71+zk-9KQYL.jpg)
![Jarrow Same Supplement 400 mg, Extra Strength, 60 Tablets - Image 3](https://m.media-amazon.com/images/I/61m3drgQYzL.jpg)
![Jarrow Same Supplement 400 mg, Extra Strength, 60 Tablets - Image 4](https://m.media-amazon.com/images/I/71jTzT0b0CL.jpg)
![Jarrow Same Supplement 400 mg, Extra Strength, 60 Tablets - Image 5](https://m.media-amazon.com/images/I/91R4+jm0DnL.jpg)

## Available Options

This product comes in different **Size** options.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Cannot recommend enough
*by 2***E on September 4, 2017*

Mental illness runs deep in my family and I've been on antidepressant medication for decades after struggling with mood since puberty. When my lovely, happy tween daughter suddenly took to her room crying unable to express the depth of despair that seemed to grab her out of nowhere, there are no words for how helpless and overwhelmed I felt. After taking her to a highly-recommended adolescent therapist, she agreed that she was likely experiencing more than just normal adolescent blues and expressed concerns about some of the dark thoughts she was starting to have. I know medication has saved my life and I was committed to doing whatever was indicated to treat her, including antidepressant medication. However, the therapist assured me that she was keeping a close eye on my daughter and felt I had some breathing room to try some supplements before starting medication. Again, I'm NOT anti-med, but the rapid brain development at her young age and some bothersome side effects prompted me to try supplements first. I researched and decided on either 5-HTP (+actually tested and used extensively in kids for other indications, -potential liver toxicity) vs. SamE (+proven efficacy and first line treatment for depression in Europe, no know SE's at any dose, -no clinical trials in kids). I decided on SamE and researched that Jarrow was a good brand for efficacy and purity. I expected a slight and gradual improvement in her mood after a few weeks. Two days at 200 mg- not much change, 2 days at 400 mg and she's markedly improved, then up to 600 mg and I could not believe what I was seeing. She was almost the same kid as before and other than a few blips (she is still a teen), she's been that way for a few months. So much so, it has me wondering if I should work with my dr. to get off cymbalta and onto SamE. A few points to consider- I'm a nurse and pretty knowledgeable about depression due to my own struggles, so I will try not to get too deep into the science but I've always suspected a genetic mutation (will test when I have $200 to spare) that causes poor methylation. Neurotransmitters like dopamine and seratonin require methylation to be available in the right amounts and there are some new treatments being researched and even sold that target methylation pathways. Sam-e targets methylation and I'd read that it helps it work better if you take a methylated folate supplement. Omega -3's, vitamin d, and Mg also have demonstrated effects on mood. So, I am also giving her a quality supplement that contains these too. We are also fortunate enough that we can pay to send her to a good behavioral therapist. I'm sure that those things are also helpful but the SamE is def. the thing that seemed to give her the immediate and noticeable boost in mood. The only negative is that it's expensive and, needless to say, insurance won't pay. But I'll take another job selling my plasma or driving for uber if I have to, because i think it's sparing my daughter the acute suffering that I've experienced first hand and seen claim the lives of people I love. FYI- I know this is a product review, not a self help article but I know ppl with depression will be reading this looking for hope. If this is you- do WHATEVER it takes (including prescribed meds or conventional treatments) to get help!

### ⭐⭐⭐⭐⭐ I am so amazed with this product
*by W***0 on October 23, 2015*

I have used Amazon for almost 10 years and I've never written a review because I'm just not the type to do so, nor do I have the time or energy to put in the effort. However, I am so amazed with this product, I have a burning desire to share my positive experience. First of all, I have tried EVERYTHING to help depression. Seriously. I've always experienced prescription drugs to be too much for my system no matter the dosing and the time I waiting the side effect out. With Sam-e, I started out taking 400s right as I woke up. (30 min before breakfast.) The first 5-6 days, I experienced heightened anxiety and insomnia. I remember one night just wide eyed thinking that it was ridiculous that I couldn't sleep. After about 5-6 days, I started to sleep normal again and the anxiety tapered off. Before I even realized it, I was just level. It's hard to explain. The edge was taken off. I've been really stressed out and depressed, and I'm in my second year of nursing school. Now, 2 months on Sam-e, the stress is minimal because I am able to control my perception on situations and life so much better. Control is something I've never had with my emotions or mental being. I've struggled with a little OCD, depression to where I wouldn't leave the house, sometimes not get out of bed and I would sit in my car for hours because I just felt like I couldn't move. I wouldn't even go into a grocery store because I didn't feel confident to deal with people or strangers. Sam-e has saved my life! That sounds so cliché but I am being as authentic as I can here. I don't feel like I'm on anything and I have zero side effects. I've not felt like I needed to adjust my dosing, as some people feel they need to bump up to higher doses to feel more of an affect. I did do a lot of research before taking Sam-e and I do take folic acid and a B complex. Apparently, those two supplements prevent a certain chemical from building up in your body from taking Sam-e. All in all, I am just so grateful to be one of the 5 star reviewers. I remember reading these same reviews praying that Sam-e would be a miracle for me and it is! My best advice is it doesn't hurt to try. Give it time.. If you feel the anxiety and insomnia, just hang in there. And take the folic acid and b complex with it; maybe that makes a difference. Wish you the best!

### ⭐⭐⭐⭐⭐ Better than an anti-depressant.
*by O***A on September 23, 2013*

For years, I was placed on chemical anti-depressants that masked my symptoms, but gave me horrid side effects and no other benefits besides lifting my mood a bit. SAM-e is a naturally occurring compound. Many people that are diagnosed with depression simply do not produce enough SAM-e naturally (whether due to genetics, poor diet, etc...) and SAM-e is all they need to see relief. I threw my anti-depressants in the garbage one day and went through horrible withdrawals. I was having a lot of difficulty and needed something that could help. I scoured the internet for natural solutions and came upon this. Everywhere I looked, they said that Jarrow Formulas was the best quality available. Within a week of taking SAM-e, I could function. Things were looking up. I was me again. That was two summers ago and would not be without it since. Here's the kicker: I recently found out I have MTHFR which is (quoting from a site so that I can explain it properly) "a genetic mutation where homocysteine levels are too high in the brain due to the fact that not enough Methylfolate is available to convert the homocysteine into Methionine, SAMe and Glutathione. Methylfolate (L-MTHF or 5-MTHF) is like a wizard changing the bad guy (Homocysteine) into good guys (SAMe and Glutathione)." So it turns out I have a medical lack of SAM-e. Also, those with MTHFR can find themselves with high folate or high B12. i.e. the body will have problems converting inactive forms of folate and B12 (like those in normal multivitamins/enriched foods) to the active forms. So the inactive folate or B12 will simply build up in your serum, also inhibiting the active forms. Ultimately, this = vitamin b12 deficiency, because everything is inhibited. MTHFR is linked to Fibromyalgia, Chronic Fatigue Syndrome, Migraines, IBS, Depression, and Alzheimer's. Alzheimer's runs in my family. Recent studies have shown that "a line of evidence suggested abnormally low levels of endogenous SAM (S-Adenosyl methionine) may play an important role in the development of Alzheimer's disease, and that SAM may therefore have therapeutic potential in the treatment of Alzheimer's disease." Other research has said "this effect is likely due to vitamin B12 deficiencies, which result in neurologic defects due to the inability to conduct one carbon transfers (with folate) in the absence of B12." I also have IBS, and SAM-e seems to help incredibly. I notice if I forget a dose. I take for my mind, my mood, my brain, and hopefully protect myself from Alzheimer's if the studies I have quoted and researched for so long are true! I love Jarrow Formulas because this SAM-e is great quality and at a reasonable price. --Anyone that is sick often or has the symptoms of MTHFR, please look into it! A simple blood test shows it.

## Frequently Bought Together

- Jarrow Formulas SAMe 400 mg, Supports Joint Health, Liver Function, Brain Metabolism, 60 Tablets, Up To a 60 Day Supply
- Jarrow Formulas® SAMe 200 mg, Supports Joint Health, Liver Function, Brain Metabolism, 60 Tablets, Up To A 60 Day Supply
- Jarrow Formulas Magnesium L-Threonate, MagMind Magtein Brain Supplements for Memory Support, 90 Veggie Capsules, Up to a 30 Day Supply

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*Product available on Desertcart Japan*
*Store origin: JP*
*Last updated: 2026-10-21*