Superior LabsBest D-Mannose NonGMO Dietary Supplement – 500mg, 120 Vegetable Capsules – Powerful Prebiotic – Boosts Urinary Tract Health – Supports Digestive Health & Liver Function

D-mannose is super effective at getting rid of urinary tract infections, and for PREVENTING them, once you get rid of them. These easy to swallow, clear vegetable capsule, 3/4 inch long X 1/4 inch wide, 500 mg, NO fillers of ANY kind, NO magnesium stearates, Dioxides, NO preservatives, or artificial ingredients, have really helped me AND my dog! The powder inside them is a very fine, white powder. Even though the capsule is easy enough to swallow, I open it up and pour out the contents onto my yogurt and onto my dogs food. This way I don't have to try to try to get my dog to eat a pill!!! I gave these to her, twice a day, in her food. WORKED beautifully to clear up her UTI!! Then i just kept giving them to her as a preventative and the vet tested her, she has been clear ever since!! I used three a day, in yogurts, smoothies, or just popped the pill. I noticed improvement within a day an half, at most. Now, I am using them to prevent a UTI coming back. I, AND the dog has not gotten a UTI again since using d-mannose!http://www.naturafoundation.co.uk/monografie/D-Mannose.htmlIn most cases, about 80 percent, urinary tract infection in adults is caused by a variety of pathogens (infectious bacteria) normally present in the intestines, especially in the rectum (colon).Nearly all infections of the lower urinary tract are caused by a few strains of E. coli bacteria - uropathogenic Escherichia coli (UPEC).Various harmless strains of E. coli are normally present in the body - but they do not belong in the urinary tract. These bacteria have multiple little hairs called cilia that function like little feet that allow them to climb from the skin around the vagina, up the urinary tube, into the bladder.If E. coli get into the bladder or the urethra (tube that carries urine from the bladder), the body has ways of fighting them off - including the obvious methods of simply flushing them out with the urine.These bacteria, however, have evolved ways of anchoring themselves to the cells of the urinary tract.The invading E. coli take advantage of receptors naturally found on the cells of the mucosal lining of the urinary tract. These receptors are like molecular "docking bays" for substances which the cells need for their normal growth and development.Like pirates in an old movie, E. coli use "grappling hooks", called type I pili, to first hook on to these receptors, and then to invade the cell. These pathogenic grappling hooks are composed of long, fibrous chains of a molecular "glue" called adhesin.Once inside the cell, E. coli can live and reproduce in safety, shielded from many of the body's defensive immune responses.In fact, these immune responses are so sophisticated that when the body detects that cells have been infected and activates the cell suicide program to destroy the bacteria, E. coli can actually flee the dying host cell before it is flushed out - and look for new cells to invade!When someone with bladder infection consumes a dose of D-mannose, the sugar is absorbed in the upper GI tract, but at a much slower rate than most other sugars. (For example, glucose is absorbed more than eight times faster.)Moreover, unlike other sugars, D-mannose is not readily converted to glycogen (and stored) in the liver, but instead passes directly into the bloodstream largely unchanged what makes it suitable for diabetics.As the D-mannose-laden blood passes through the kidneys, a considerable proportion of the sugar is extracted and added to the urine.The D-mannose-sweetened urine flows from the kidneys through the ureters to the bladder and on to the urethra, literally sugar-coating any free-floating E. coli it might encounter, so they cannot stick to cells any more.It also unsticks most of the E. coli already "velcro-ed" to the inner surface of the bladder and urinary tract, ultimately flushing them all down the drain.Several years of clinical experience have shown that D-Mannose is just as effective at curing bladder infections caused by E. coli as antibiotic drugs

I have had issues with reoccurring UTIs since I was 19. 24 years of these things that reliably would show up at 2am in the morning on a Sat.In my youth I could flush out with water and 100% cranberry juice plus a little help from the Azo pain relief to get through that first day. Sometimes the urgency and pain was so terrible I would just go straight to ER. Then it got to the point where I could call my OBGYN to let them know I was having one and they would prescribe Bactrim to which eventually I became sensitive-I would get a cough. Then I was prescribed Macrobid during my 2 Pregnancies. I was sent to a urologist that did a sonogram of my bladder to determine if there was anything that was causing these frequent UTIs. Nothing other than the location of my urethra which made me prone to them and the fact that the inside of my bladder looked like an elderly woman's. I also was then prescribed Macrobid 50mg as a prophylactic after sex (which was usually the instigator for me to get one). In the last year, I started to get an RX of Cipro when the UTI would not go away after the first round of Macrobid didn't work. In the last year I was starting to get a UTI almost one every month and a half. But as I've aged I would get them 2 nights after indulging in alcohol. Even though I'm diligent in drinking at least 64 oz water every day and up it to a min of 80oz of water the following day post drinking alcohol to rehydrate. I was miserable. After my last round of Macrobid, then Cipro and then 3 weeks later another round of Macrobid I decided that was it. No more antibiotics and that was going to be my last round of antibiotics. My doctor said it looked like I'd have to go down the path of taking antibiotics every day to prevent my reoccurring UTIs and that I did not want and had already avoided for years.My hair was falling out I believe as a side effect to the Macrobid. It had been for years and in the last round of Macrobid it was falling out even significantly more and then I read it was a side effect. After the first time I took Cipro my shoulder started to bother me. After the second time my knee started to pain me. After the third time I took Cipro my hip started to bother me. At first I thought it was from my workouts, I box regularly as well as dance Tahitian, but read that joint issues are a side-effect of Cipro. And because of my boxing and dancing, I couldn't afford to have joint issues. I'd already lessened my boxing to 3x/week rotating in spin to avoid the shoulder issue I had, but my dancing was only 2x/week and with performances looming I just couldn't have further issues. So before my RX ran out and would potentially need to take Cipro again, I researched D-Mannose, purchased one bottle of D-Mannose through Amazon prime on Aug 23, 2016. Once I finished my Macrobid RX I started taking D-Mannose on Aug 26th. I still felt twinges of UTI issues and felt very hopeful because like I said, I was through taking antibiotics. I started taking 2 capsules 3x/day for a few days. Those twinges went away. Then I went down to 2 capsules 2x/day for maintenance. When I know I will be indulging in alcohol I make sure I take 2 capsules before bed. Then up my dose to 2 caps/every few hours until I've gotten through the 2 days post drinking. I have not had a UTI since. I started taking 3 weekends ago with 3 weekends of celebrations and parties all involving alcohol. My bladder feels great. I am hopeful that this continued regimen plus the addition of probiotics 2x/day (yogurt not pills for 1 week now) will prevent further occurrences of UTI and subsequent use of antibiotics. I hate taking meds, I don't even take pain killers. The only time I gave free reign was to get over a UTI. I feel freedom from those drugs at last.So long story short, nothing worked to prevent my UTIs for the past 24 years: drinking tons of water, drinking hot lemon water first thing in the morning for the past 13 years, pee-ing before and after sex, cranberry pills, my prophylactic RX of Macrobid. I even started oil-pulling every morning starting in July. But D-Mannose has worked for me for the last 3 weeks. This is the longest I've gone without a UTI this year even with behavior that prior to taking D-mannose would have caused me to have a UTI without a doubt. If you're reading this review then you must be going through similar issues. It works for me and I'd like to come back in a year and say I've been UTI free for a year. It's been at least decade since I went longer than 6 months without one.On a side note I did feel bloated the first week I started taking regularly but that has since gone away.

After 1 day of use, I've noticed such a drastic improvement! I'm normally very skeptical of trying any meds/ prescription/ over the counter drugs/ vitamins that come recommended. However the experience of having a UTI can be very painful on all levels. Therefore after investigating & conducting some extensive research, I came across this product. This particular brand of choice was found to be all natural w/ no artificial fillers and came highly recommended on top of that. So I really pondered the thought of giving it a try vs suffering the continued effects of a UTI... which quite honestly I've only experienced twice in my lifetime. After careful thought & consideration, I decided that NOW was the time to ACT. I went ahead & purchased this product thru Amazon. I received the item yesterday and immediately took 2 pills w/ a meal. The next morning I felt as though I was on cloud 9! The UTI symptoms and effects that I had been dealing w/ for the past 1.5 weeks had subsided after 1 day. Again I am always very skeptical when it comes to trying (new) things. But HONESTLY this is one of the best purchases that I've made w/o regret. As I appear to be symptom free after 1 day then I strongly believe that this product should be given a try by those considering it. I wasn't a believer until I tried it for myself... AND IT WORKS!!!! No side effects so far! Just a great product that comes very highly recommended. Temporarily I will continue to use as suggested w/ confidence in knowing that I won't be disappointed w/ the results!